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Agreement Between Trend-Based and Qualitative Analysis of the Retinal Nerve Fiber Layer Thickness for Glaucoma Progression on Spectral-Domain Optical Coherence Tomography

Publication ,  Journal Article
Thompson, AC; Li, A; Asrani, S
Published in: Ophthalmology and Therapy
September 1, 2021

Introduction: To evaluate the agreement between trend-based analysis and qualitative assessment of the retinal nerve fiber layer (RNFL) thickness for glaucomatous progression on spectral-domain optical coherence tomography (SDOCT). Methods: Retrospective review of 190 eyes from 103 patients with glaucoma or suspected glaucoma that underwent SDOCT imaging during four consecutive clinic visits. Trend-based progression was characterized by a significantly negative slope. Progression by qualitative analysis was determined by review of raw SDOCT B-scans. Results: The slope was significantly greater in those with progression than without progression for both trend-based and qualitative analysis (p < 0.001). However, the qualitative grading classified a significantly greater proportion of eyes as progressing compared to trend-based analysis in both the superotemporal (ST) (23.2% vs. 10.5%, p = 0.001) and inferotemporal (IT) RNFL (27.4% vs 8.4%, p < 0.001). The trend-based and qualitative classifications of progression showed poor agreement in both the ST (kappa = 0.0135) and IT RNFL (kappa = 0.1222). The agreement between trend-based and qualitative analysis was lower for eyes with artifacts (ST = 58.11%; IT = 68.7%) than those without artifacts (ST = 80.2%; IT = 74.8%). Moreover, among eyes with artifacts, there was no significant difference in slope between those qualitatively categorized as progressing versus not progressing (p > 0.05). Conclusions: Poor agreement was found between a trend-based and qualitative analysis of change in RNFL on SDOCT. Careful qualitative review of SDOCT imaging may identify specific areas of glaucoma progression not captured by trend-based methods, especially in the presence of artifacts. Such an approach may also prove useful for detecting glaucoma progression in a clinical setting when there are few data points available.

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Published In

Ophthalmology and Therapy

DOI

EISSN

2193-6528

ISSN

2193-8245

Publication Date

September 1, 2021

Volume

10

Issue

3

Start / End Page

629 / 642

Related Subject Headings

  • 3212 Ophthalmology and optometry
 

Citation

APA
Chicago
ICMJE
MLA
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Thompson, A. C., Li, A., & Asrani, S. (2021). Agreement Between Trend-Based and Qualitative Analysis of the Retinal Nerve Fiber Layer Thickness for Glaucoma Progression on Spectral-Domain Optical Coherence Tomography. Ophthalmology and Therapy, 10(3), 629–642. https://doi.org/10.1007/s40123-021-00355-0
Thompson, A. C., A. Li, and S. Asrani. “Agreement Between Trend-Based and Qualitative Analysis of the Retinal Nerve Fiber Layer Thickness for Glaucoma Progression on Spectral-Domain Optical Coherence Tomography.” Ophthalmology and Therapy 10, no. 3 (September 1, 2021): 629–42. https://doi.org/10.1007/s40123-021-00355-0.
Thompson, A. C., et al. “Agreement Between Trend-Based and Qualitative Analysis of the Retinal Nerve Fiber Layer Thickness for Glaucoma Progression on Spectral-Domain Optical Coherence Tomography.” Ophthalmology and Therapy, vol. 10, no. 3, Sept. 2021, pp. 629–42. Scopus, doi:10.1007/s40123-021-00355-0.
Journal cover image

Published In

Ophthalmology and Therapy

DOI

EISSN

2193-6528

ISSN

2193-8245

Publication Date

September 1, 2021

Volume

10

Issue

3

Start / End Page

629 / 642

Related Subject Headings

  • 3212 Ophthalmology and optometry