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Prostate cancer disparities in Hispanics by country of origin: a nationwide population-based analysis.

Publication ,  Journal Article
Dobbs, RW; Malhotra, NR; Abern, MR; Moreira, DM
Published in: Prostate Cancer Prostatic Dis
March 2019

BACKGROUND: We sought to evaluate prostate cancer (PCa) characteristics and outcomes of Hispanics living in the United States by country of origin in the Surveillance, Epidemiology and End Results (SEER) program. METHODS: Retrospective analysis of 72,134 adult Hispanics with PCa between 1995 and 2014. Origin was Mexican (N = 16,995; 24%), South/Central American (N = 6949; 10%), Puerto Rican (N = 3582; 5%), Cuban (N = 2587; 4%), Dominican (N = 725; 1%), Hispanic not specified (NOS, N = 41,296; 57%), as coded by SEER. Patient and PCa characteristics were analyzed with chi-square and Kruskal-Wallis tests. Overall and PCa survival were analyzed with Kaplan-Meier and Cox models adjusting for baseline variables. RESULTS: At diagnosis, Mexicans had more advanced stage, higher prostate-specific antigen, and higher Gleason score while Cubans and Dominicans had more favorable PCa at diagnosis (all P < 0.05). After a median follow-up of 69 months, 20,317 men died, including 6223 PCa deaths. Compared to Mexicans, Cubans (HR = 1.22, 95% CI = [1.14-1.30]) and Puerto Ricans (HR = 1.15 [1.08-1.22]) had worse overall survival while Dominicans (HR = 0.76 [0.64-0.91]), South/Central Americans (HR = 0.68 [0.65-0.72]), and NOS (HR = 0.81 [0.78-0.84]) had better overall survival. Compared to Mexicans, Cubans (HR = 1.08 [0.96-1.22]) and Puerto Ricans (HR = 1.03 [0.92-1.15]) had similar PCa survival while Dominicans (HR = 0.72 [0.53-0.98]), South/Central Americans (HR = 0.67 [0.60-0.74]), and NOS (HR = 0.68 [0.64-0.73]) had significantly better PCa survival. CONCLUSIONS: Among Hispanics in the United States, disparities in PCa characteristics and survival by country of origin exist, with Dominicans, South/Central Americans, and Hispanic NOS having better PCa survival compared to Mexicans, Cubans, and Puerto Ricans.

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Published In

Prostate Cancer Prostatic Dis

DOI

EISSN

1476-5608

Publication Date

March 2019

Volume

22

Issue

1

Start / End Page

159 / 167

Location

England

Related Subject Headings

  • Urology & Nephrology
  • United States
  • Survival Rate
  • Socioeconomic Factors
  • SEER Program
  • Prostatic Neoplasms
  • Population Surveillance
  • Male
  • Humans
  • Hispanic or Latino
 

Citation

APA
Chicago
ICMJE
MLA
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Dobbs, R. W., Malhotra, N. R., Abern, M. R., & Moreira, D. M. (2019). Prostate cancer disparities in Hispanics by country of origin: a nationwide population-based analysis. Prostate Cancer Prostatic Dis, 22(1), 159–167. https://doi.org/10.1038/s41391-018-0097-y
Dobbs, Ryan W., Neha R. Malhotra, Michael R. Abern, and Daniel M. Moreira. “Prostate cancer disparities in Hispanics by country of origin: a nationwide population-based analysis.Prostate Cancer Prostatic Dis 22, no. 1 (March 2019): 159–67. https://doi.org/10.1038/s41391-018-0097-y.
Dobbs RW, Malhotra NR, Abern MR, Moreira DM. Prostate cancer disparities in Hispanics by country of origin: a nationwide population-based analysis. Prostate Cancer Prostatic Dis. 2019 Mar;22(1):159–67.
Dobbs, Ryan W., et al. “Prostate cancer disparities in Hispanics by country of origin: a nationwide population-based analysis.Prostate Cancer Prostatic Dis, vol. 22, no. 1, Mar. 2019, pp. 159–67. Pubmed, doi:10.1038/s41391-018-0097-y.
Dobbs RW, Malhotra NR, Abern MR, Moreira DM. Prostate cancer disparities in Hispanics by country of origin: a nationwide population-based analysis. Prostate Cancer Prostatic Dis. 2019 Mar;22(1):159–167.

Published In

Prostate Cancer Prostatic Dis

DOI

EISSN

1476-5608

Publication Date

March 2019

Volume

22

Issue

1

Start / End Page

159 / 167

Location

England

Related Subject Headings

  • Urology & Nephrology
  • United States
  • Survival Rate
  • Socioeconomic Factors
  • SEER Program
  • Prostatic Neoplasms
  • Population Surveillance
  • Male
  • Humans
  • Hispanic or Latino