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Case series of fatal Leptospira spp./dengue virus co-infections-Puerto Rico, 2010-2012.

Publication ,  Journal Article
Pérez Rodríguez, NM; Galloway, R; Blau, DM; Traxler, R; Bhatnagar, J; Zaki, SR; Rivera, A; Torres, JV; Noyd, D; Santiago-Albizu, XE; Bower, WA ...
Published in: Am J Trop Med Hyg
October 2014

Co-infection with pathogens that cause acute febrile illness creates a diagnostic challenge as a result of overlapping clinical manifestations. Here, we describe four fatal cases of Leptospira species/dengue virus co-infection in Puerto Rico. Although all patients sought care early, antibiotic administration was delayed for most. Steroids were administered to all patients, in most cases before antibiotics. These cases show the need for clinicians evaluating patients in or recently returned from the tropics with acute febrile illness to consider both dengue and leptospirosis. Furthermore, they illustrate the need for nucleic acid- or antigen-based rapid diagnostic tests to enable timely patient diagnosis and management. In particular, antibiotic therapy should be initiated early for patients with suspected leptospirosis, and steroids should not be administered to patients with suspected dengue.

Published In

Am J Trop Med Hyg

DOI

EISSN

1476-1645

Publication Date

October 2014

Volume

91

Issue

4

Start / End Page

760 / 765

Location

United States

Related Subject Headings

  • Young Adult
  • Tropical Medicine
  • Steroids
  • Puerto Rico
  • Middle Aged
  • Male
  • Leptospirosis
  • Leptospira
  • Humans
  • Fatal Outcome
 

Citation

APA
Chicago
ICMJE
MLA
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Pérez Rodríguez, N. M., Galloway, R., Blau, D. M., Traxler, R., Bhatnagar, J., Zaki, S. R., … Sharp, T. M. (2014). Case series of fatal Leptospira spp./dengue virus co-infections-Puerto Rico, 2010-2012. Am J Trop Med Hyg, 91(4), 760–765. https://doi.org/10.4269/ajtmh.14-0220
Pérez Rodríguez, Nicole M., Renee Galloway, Dianna M. Blau, Rita Traxler, Julu Bhatnagar, Sherif R. Zaki, Aidsa Rivera, et al. “Case series of fatal Leptospira spp./dengue virus co-infections-Puerto Rico, 2010-2012.Am J Trop Med Hyg 91, no. 4 (October 2014): 760–65. https://doi.org/10.4269/ajtmh.14-0220.
Pérez Rodríguez NM, Galloway R, Blau DM, Traxler R, Bhatnagar J, Zaki SR, et al. Case series of fatal Leptospira spp./dengue virus co-infections-Puerto Rico, 2010-2012. Am J Trop Med Hyg. 2014 Oct;91(4):760–5.
Pérez Rodríguez, Nicole M., et al. “Case series of fatal Leptospira spp./dengue virus co-infections-Puerto Rico, 2010-2012.Am J Trop Med Hyg, vol. 91, no. 4, Oct. 2014, pp. 760–65. Pubmed, doi:10.4269/ajtmh.14-0220.
Pérez Rodríguez NM, Galloway R, Blau DM, Traxler R, Bhatnagar J, Zaki SR, Rivera A, Torres JV, Noyd D, Santiago-Albizu XE, Rivera García B, Tomashek KM, Bower WA, Sharp TM. Case series of fatal Leptospira spp./dengue virus co-infections-Puerto Rico, 2010-2012. Am J Trop Med Hyg. 2014 Oct;91(4):760–765.

Published In

Am J Trop Med Hyg

DOI

EISSN

1476-1645

Publication Date

October 2014

Volume

91

Issue

4

Start / End Page

760 / 765

Location

United States

Related Subject Headings

  • Young Adult
  • Tropical Medicine
  • Steroids
  • Puerto Rico
  • Middle Aged
  • Male
  • Leptospirosis
  • Leptospira
  • Humans
  • Fatal Outcome