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Animal Models of Metastatic Lesions to the Spine: A Focus on Epidural Spinal Cord Compression.

Publication ,  Journal Article
Price, MJ; Baëta, C; Dalton, TE; Nguyen, A; Lavau, C; Pennington, Z; Sciubba, DM; Goodwin, CR
Published in: World Neurosurg
November 2021

Epidural spinal cord compression (ESCC) secondary to spine metastases is one of the most devastating sequelae of primary cancer as it may lead to muscle weakness, paresthesia, pain, and paralysis. Spine metastases occur through a multistep process that can result in eventual ESCC; however, the lack of a preclinical model to effectively recapitulate each step of this metastatic cascade and the symptom burden of ESCC has limited our understanding of this disease process. In this review, we discuss animal models that best recapitulate ESCC. We start with a broad discussion of commonly used models of bone metastasis and end with a focused discussion of models used to specifically study ESCC. Orthotopic models offer the most authentic recapitulation of metastasis development; however, they rarely result in symptomatic ESCC and are challenging to replicate. Conversely, models that involve injection of tumor cells directly into the bloodstream or bone better mimic the symptoms of ESCC; however, they provide limited insight into the epithelial to mesenchymal transition and natural hematogenous spread of tumor cells. Therefore, until an ideal model is created, it is critical to select an animal model that is specifically designed to answer the scientific question of interest.

Duke Scholars

Published In

World Neurosurg

DOI

EISSN

1878-8769

Publication Date

November 2021

Volume

155

Start / End Page

122 / 134

Location

United States

Related Subject Headings

  • Spinal Neoplasms
  • Spinal Cord Compression
  • Humans
  • Epithelial-Mesenchymal Transition
  • Epidural Space
  • Disease Models, Animal
  • Cell Line, Tumor
  • Animals
  • 3209 Neurosciences
  • 3202 Clinical sciences
 

Citation

APA
Chicago
ICMJE
MLA
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Price, M. J., Baëta, C., Dalton, T. E., Nguyen, A., Lavau, C., Pennington, Z., … Goodwin, C. R. (2021). Animal Models of Metastatic Lesions to the Spine: A Focus on Epidural Spinal Cord Compression. World Neurosurg, 155, 122–134. https://doi.org/10.1016/j.wneu.2021.07.121
Price, Meghan J., César Baëta, Tara E. Dalton, Annee Nguyen, Catherine Lavau, Zach Pennington, Daniel M. Sciubba, and C Rory Goodwin. “Animal Models of Metastatic Lesions to the Spine: A Focus on Epidural Spinal Cord Compression.World Neurosurg 155 (November 2021): 122–34. https://doi.org/10.1016/j.wneu.2021.07.121.
Price MJ, Baëta C, Dalton TE, Nguyen A, Lavau C, Pennington Z, et al. Animal Models of Metastatic Lesions to the Spine: A Focus on Epidural Spinal Cord Compression. World Neurosurg. 2021 Nov;155:122–34.
Price, Meghan J., et al. “Animal Models of Metastatic Lesions to the Spine: A Focus on Epidural Spinal Cord Compression.World Neurosurg, vol. 155, Nov. 2021, pp. 122–34. Pubmed, doi:10.1016/j.wneu.2021.07.121.
Price MJ, Baëta C, Dalton TE, Nguyen A, Lavau C, Pennington Z, Sciubba DM, Goodwin CR. Animal Models of Metastatic Lesions to the Spine: A Focus on Epidural Spinal Cord Compression. World Neurosurg. 2021 Nov;155:122–134.
Journal cover image

Published In

World Neurosurg

DOI

EISSN

1878-8769

Publication Date

November 2021

Volume

155

Start / End Page

122 / 134

Location

United States

Related Subject Headings

  • Spinal Neoplasms
  • Spinal Cord Compression
  • Humans
  • Epithelial-Mesenchymal Transition
  • Epidural Space
  • Disease Models, Animal
  • Cell Line, Tumor
  • Animals
  • 3209 Neurosciences
  • 3202 Clinical sciences