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IRTA1 positivity helps identify a MALT-lymphoma-like subset of primary cutaneous marginal zone lymphomas, largely but not exclusively defined by IgM expression.

Publication ,  Journal Article
Carlsen, ED; Bhavsar, S; Cook, JR; Swerdlow, SH
Published in: J Cutan Pathol
January 2022

BACKGROUND: It has been proposed that primary cutaneous marginal zone lymphomas (PCMZLs) include a MALT-lymphoma-like IgM+ subset and a class-switched subset, which is unlike most other MALT lymphomas. Whether expression of the MALT lymphoma-associated biomarkers IRTA1 and MNDA would support this concept and whether they might help explain why some patients have both subtypes is uncertain. METHODS: Twenty-five PCMZLs from 21 patients were stained for IRTA1 by in situ hybridization and for MNDA by immunohistochemistry. In two patients, polymerase chain reaction (PCR)-based B-cell clonality studies were performed on biopsy specimens of metachronous lesions, which expressed different heavy chains. All results were correlated with the histopathologic and clinical findings. RESULTS: Five of six IgM+ PCMZLs were IRTA1+ vs three of 18 evaluable class-switched cases (P = 0.0069). Two of the class-switched IRTA1+ cases were in patients with clonally-related IRTA1+ IgM+ PCMZLs. IRTA1 positivity showed a statistically significant correlation with several MALT-lymphoma-associated histopathologic findings. In contrast, all PCMZL cases showed at least some MNDA expression with no differences between IgM+ and class-switched cases. CONCLUSIONS: IRTA1 identifies MALT-lymphoma-like PCMZLs that are largely but not exclusively IgM+. This supports the concept of two PCMZL subsets but suggests their distinction should not be based solely on their heavy chain expression.

Duke Scholars

Published In

J Cutan Pathol

DOI

EISSN

1600-0560

Publication Date

January 2022

Volume

49

Issue

1

Start / End Page

55 / 60

Location

United States

Related Subject Headings

  • Skin Neoplasms
  • Receptors, Fc
  • Neoplasm Proteins
  • Middle Aged
  • Male
  • Lymphoma, B-Cell, Marginal Zone
  • Immunoglobulin M
  • Humans
  • Gene Expression Regulation, Neoplastic
  • Female
 

Citation

APA
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MLA
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Carlsen, E. D., Bhavsar, S., Cook, J. R., & Swerdlow, S. H. (2022). IRTA1 positivity helps identify a MALT-lymphoma-like subset of primary cutaneous marginal zone lymphomas, largely but not exclusively defined by IgM expression. J Cutan Pathol, 49(1), 55–60. https://doi.org/10.1111/cup.14111
Carlsen, Eric D., Shweta Bhavsar, James R. Cook, and Steven H. Swerdlow. “IRTA1 positivity helps identify a MALT-lymphoma-like subset of primary cutaneous marginal zone lymphomas, largely but not exclusively defined by IgM expression.J Cutan Pathol 49, no. 1 (January 2022): 55–60. https://doi.org/10.1111/cup.14111.
Carlsen, Eric D., et al. “IRTA1 positivity helps identify a MALT-lymphoma-like subset of primary cutaneous marginal zone lymphomas, largely but not exclusively defined by IgM expression.J Cutan Pathol, vol. 49, no. 1, Jan. 2022, pp. 55–60. Pubmed, doi:10.1111/cup.14111.
Journal cover image

Published In

J Cutan Pathol

DOI

EISSN

1600-0560

Publication Date

January 2022

Volume

49

Issue

1

Start / End Page

55 / 60

Location

United States

Related Subject Headings

  • Skin Neoplasms
  • Receptors, Fc
  • Neoplasm Proteins
  • Middle Aged
  • Male
  • Lymphoma, B-Cell, Marginal Zone
  • Immunoglobulin M
  • Humans
  • Gene Expression Regulation, Neoplastic
  • Female