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Urinary Biomarkers of Renal Injury KIM-1 and NGAL: Reference Intervals for Healthy Pediatric Population in Sri Lanka.

Publication ,  Journal Article
De Silva, PMCS; Gunasekara, TDKSC; Gunarathna, SD; Sandamini, PMMA; Pinipa, RAI; Ekanayake, EMDV; Thakshila, WAKG; Jayasinghe, SS; Chandana, EPS ...
Published in: Children (Basel, Switzerland)
August 2021

Emerging renal biomarkers (e.g., kidney injury molecule-1 (KIM-1) and neutrophil gelatinase-associated lipocalin (NGAL)) are thought to be highly sensitive in diagnosing renal injury. However, global data on reference intervals for emerging biomarkers in younger populations are lacking. Here, we aimed to determine reference intervals for KIM-1 and NGAL across a pediatric population in Sri Lanka; a country significantly impacted by the emergence of chronic kidney disease of unexplained etiology (CKDu). Urine samples were collected from children (10-18 years) with no prior record of renal diseases from the dry climatic zone of Sri Lanka (N = 909). Urinary KIM-1 and NGAL concentrations were determined using the enzyme-linked immunosorbent assay (ELISA) and adjusted to urinary creatinine. Biomarker levels were stratified by age and gender, and reference intervals derived with quantile regression (2.5th, 50th, and 97.5th quantiles) were expressed at 95% CI. The range of median reference intervals for urinary KIM-1 and NGAL in children were 0.081-0.426 ng/mg Cr, 2.966-4.850 ng/mg Cr for males, and 0.0780-0.5076 ng/mg Cr, 2.0850-3.4960 ng/mg Cr for females, respectively. Renal biomarkers showed weak correlations with age, gender, ACR, and BMI. Our findings provide reference intervals to facilitate screening to detect early renal damage, especially in rural communities that are impacted by CKDu.

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Published In

Children (Basel, Switzerland)

DOI

EISSN

2227-9067

ISSN

2227-9067

Publication Date

August 2021

Volume

8

Issue

8

Start / End Page

684

Related Subject Headings

  • 4206 Public health
  • 3213 Paediatrics
 

Citation

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De Silva, P. M. C. S., Gunasekara, T. D. K. S. C., Gunarathna, S. D., Sandamini, P. M. M. A., Pinipa, R. A. I., Ekanayake, E. M. D. V., … Jayasundara, N. (2021). Urinary Biomarkers of Renal Injury KIM-1 and NGAL: Reference Intervals for Healthy Pediatric Population in Sri Lanka. Children (Basel, Switzerland), 8(8), 684. https://doi.org/10.3390/children8080684
De Silva, P Mangala C. S., T. D. K. S. C. Gunasekara, S. D. Gunarathna, P. M. M. A. Sandamini, R. A. I. Pinipa, E. M. D. V. Ekanayake, W. A. K. G. Thakshila, S. S. Jayasinghe, E. P. S. Chandana, and Nishad Jayasundara. “Urinary Biomarkers of Renal Injury KIM-1 and NGAL: Reference Intervals for Healthy Pediatric Population in Sri Lanka.Children (Basel, Switzerland) 8, no. 8 (August 2021): 684. https://doi.org/10.3390/children8080684.
De Silva PMCS, Gunasekara TDKSC, Gunarathna SD, Sandamini PMMA, Pinipa RAI, Ekanayake EMDV, et al. Urinary Biomarkers of Renal Injury KIM-1 and NGAL: Reference Intervals for Healthy Pediatric Population in Sri Lanka. Children (Basel, Switzerland). 2021 Aug;8(8):684.
De Silva, P. Mangala C. S., et al. “Urinary Biomarkers of Renal Injury KIM-1 and NGAL: Reference Intervals for Healthy Pediatric Population in Sri Lanka.Children (Basel, Switzerland), vol. 8, no. 8, Aug. 2021, p. 684. Epmc, doi:10.3390/children8080684.
De Silva PMCS, Gunasekara TDKSC, Gunarathna SD, Sandamini PMMA, Pinipa RAI, Ekanayake EMDV, Thakshila WAKG, Jayasinghe SS, Chandana EPS, Jayasundara N. Urinary Biomarkers of Renal Injury KIM-1 and NGAL: Reference Intervals for Healthy Pediatric Population in Sri Lanka. Children (Basel, Switzerland). 2021 Aug;8(8):684.

Published In

Children (Basel, Switzerland)

DOI

EISSN

2227-9067

ISSN

2227-9067

Publication Date

August 2021

Volume

8

Issue

8

Start / End Page

684

Related Subject Headings

  • 4206 Public health
  • 3213 Paediatrics