Skip to main content
Journal cover image

Translating pediatric urodynamics from clinic into collaborative research: Lessons and recommendations from the UMPIRE study group.

Publication ,  Journal Article
Yerkes, EB; Cheng, EY; Wiener, JS; Austin, JC; Tu, DD; Joseph, DB; Routh, JC; Tanaka, ST
Published in: J Pediatr Urol
October 2021

Pediatric patients present unique challenges in the performance and interpretation of urodynamic studies. Interpretation of urodynamics to guide clinical management at an institutional level is accepted as reliable. Challenges arise however when multi-site collaborations incorporate urodynamics into study design to determine primary or secondary outcomes or to direct decision-making. Although standardized terminology has been established by ICCS, the application of this shared language to performance and interpretation of pediatric urodynamics to across multiple sites may not be intuitive or reliable. With a primary goal of defining the care necessary to protect future renal function, the UMPIRE protocol (Urologic Management to Preserve Initial REnal function) utilizes a urodynamics-based risk stratification to determine medical management for infants with myelomeningocele. Iterative changes in the protocol are based upon the clinical progress of the enrolled children. Despite a team experienced in subtleties of urodynamics and despite efforts to minimize variability across sites, the UMPIRE study group identified several areas in which the language of urodynamics required additional clarification or creation of more explicit definitions to standardize performance and interpretation across sites. This article reviews the foundations of current urodynamics practice, describes limitations and challenges unique to pediatric studies, and the shares the humble lessons learned by the UMPIRE study group on their journey toward standardized urodynamic language for management of infants and children with myelomeningocele.

Duke Scholars

Altmetric Attention Stats
Dimensions Citation Stats

Published In

J Pediatr Urol

DOI

EISSN

1873-4898

Publication Date

October 2021

Volume

17

Issue

5

Start / End Page

716 / 725

Location

England

Related Subject Headings

  • Urology & Nephrology
  • Urology
  • Urologic Surgical Procedures
  • Urodynamics
  • Meningomyelocele
  • Infant
  • Humans
  • Forecasting
  • Child
  • 3213 Paediatrics
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Yerkes, E. B., Cheng, E. Y., Wiener, J. S., Austin, J. C., Tu, D. D., Joseph, D. B., … Tanaka, S. T. (2021). Translating pediatric urodynamics from clinic into collaborative research: Lessons and recommendations from the UMPIRE study group. J Pediatr Urol, 17(5), 716–725. https://doi.org/10.1016/j.jpurol.2021.05.004
Yerkes, Elizabeth B., Earl Y. Cheng, John S. Wiener, J Christopher Austin, Duong D. Tu, David B. Joseph, Jonathan C. Routh, and Stacy T. Tanaka. “Translating pediatric urodynamics from clinic into collaborative research: Lessons and recommendations from the UMPIRE study group.J Pediatr Urol 17, no. 5 (October 2021): 716–25. https://doi.org/10.1016/j.jpurol.2021.05.004.
Yerkes EB, Cheng EY, Wiener JS, Austin JC, Tu DD, Joseph DB, et al. Translating pediatric urodynamics from clinic into collaborative research: Lessons and recommendations from the UMPIRE study group. J Pediatr Urol. 2021 Oct;17(5):716–25.
Yerkes, Elizabeth B., et al. “Translating pediatric urodynamics from clinic into collaborative research: Lessons and recommendations from the UMPIRE study group.J Pediatr Urol, vol. 17, no. 5, Oct. 2021, pp. 716–25. Pubmed, doi:10.1016/j.jpurol.2021.05.004.
Yerkes EB, Cheng EY, Wiener JS, Austin JC, Tu DD, Joseph DB, Routh JC, Tanaka ST. Translating pediatric urodynamics from clinic into collaborative research: Lessons and recommendations from the UMPIRE study group. J Pediatr Urol. 2021 Oct;17(5):716–725.
Journal cover image

Published In

J Pediatr Urol

DOI

EISSN

1873-4898

Publication Date

October 2021

Volume

17

Issue

5

Start / End Page

716 / 725

Location

England

Related Subject Headings

  • Urology & Nephrology
  • Urology
  • Urologic Surgical Procedures
  • Urodynamics
  • Meningomyelocele
  • Infant
  • Humans
  • Forecasting
  • Child
  • 3213 Paediatrics