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Value of Intratumoral Metabolic Heterogeneity and Quantitative 18F-FDG PET/CT Parameters to Predict Prognosis in Patients With HPV-Positive Primary Oropharyngeal Squamous Cell Carcinoma.

Publication ,  Journal Article
Mena, E; Taghipour, M; Sheikhbahaei, S; Jha, AK; Rahmim, A; Solnes, L; Subramaniam, RM
Published in: Clin Nucl Med
May 2017

OBJECTIVE: The aim of this study was to evaluate the impact of intratumoral metabolic heterogeneity and quantitative FDG PET/CT imaging parameters for predicting patient outcomes in primary oropharyngeal squamous cell cancer (OPSCC). PATIENTS AND METHODS: We retrospectively investigated 105 patients with HPV-positive OPSCC. SUVmax and metabolic tumor volume (MTV) were measured for the primary tumors and when available for the metastatic sites. Primary tumor intratumoral metabolic heterogeneity was calculated as the area under a cumulative SUV volume histograms curve (AUC-CSH). The median follow-up time was 35.4 months (range, 3-92 months). Outcome end point was event-free survival (EFS). Kaplan-Meier survival plots and Cox regression analyses were performed. RESULTS: Of the 105 patients included, 19 patients relapsed and 11 deceased during the study period. AUC-CSH indexes were associated with EFS using PET gradient-based (P = 0.034) and 50% threshold (P = 0.02) segmentation methods, on multivariate analysis. Kaplan-Meier survival analysis using optimum cutoff of 16.7 SUVmax and 12.7 mL total MTV were significant predictors of EFS. Combining SUVmax and AUC-CSH index in 3 subgroups, patients with higher intratumoral heterogeneity and higher SUVmax were associated with worse outcome (log-rank, P = 0.026). Similarly, patients with higher intratumoral heterogeneity tumors and higher MTV had worse prognosis (log-rank, P = 0.022). CONCLUSIONS: Intratumoral metabolic heterogeneity using FDG PET was a prognostic factor for EFS in patients with primary HPV (+) OPSCC. The combined predictive effect of FDG avidity, metabolic tumor burden, and intratumoral heterogeneity provided prognostic survival information in these patients.

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Published In

Clin Nucl Med

DOI

EISSN

1536-0229

Publication Date

May 2017

Volume

42

Issue

5

Start / End Page

e227 / e234

Location

United States

Related Subject Headings

  • Survival Analysis
  • Radiopharmaceuticals
  • Predictive Value of Tests
  • Positron Emission Tomography Computed Tomography
  • Oropharyngeal Neoplasms
  • Nuclear Medicine & Medical Imaging
  • Middle Aged
  • Male
  • Humans
  • Fluorodeoxyglucose F18
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Mena, E., Taghipour, M., Sheikhbahaei, S., Jha, A. K., Rahmim, A., Solnes, L., & Subramaniam, R. M. (2017). Value of Intratumoral Metabolic Heterogeneity and Quantitative 18F-FDG PET/CT Parameters to Predict Prognosis in Patients With HPV-Positive Primary Oropharyngeal Squamous Cell Carcinoma. Clin Nucl Med, 42(5), e227–e234. https://doi.org/10.1097/RLU.0000000000001578
Mena, Esther, Mehdi Taghipour, Sara Sheikhbahaei, Abhinav K. Jha, Arman Rahmim, Lilja Solnes, and Rathan M. Subramaniam. “Value of Intratumoral Metabolic Heterogeneity and Quantitative 18F-FDG PET/CT Parameters to Predict Prognosis in Patients With HPV-Positive Primary Oropharyngeal Squamous Cell Carcinoma.Clin Nucl Med 42, no. 5 (May 2017): e227–34. https://doi.org/10.1097/RLU.0000000000001578.
Mena, Esther, et al. “Value of Intratumoral Metabolic Heterogeneity and Quantitative 18F-FDG PET/CT Parameters to Predict Prognosis in Patients With HPV-Positive Primary Oropharyngeal Squamous Cell Carcinoma.Clin Nucl Med, vol. 42, no. 5, May 2017, pp. e227–34. Pubmed, doi:10.1097/RLU.0000000000001578.
Mena E, Taghipour M, Sheikhbahaei S, Jha AK, Rahmim A, Solnes L, Subramaniam RM. Value of Intratumoral Metabolic Heterogeneity and Quantitative 18F-FDG PET/CT Parameters to Predict Prognosis in Patients With HPV-Positive Primary Oropharyngeal Squamous Cell Carcinoma. Clin Nucl Med. 2017 May;42(5):e227–e234.

Published In

Clin Nucl Med

DOI

EISSN

1536-0229

Publication Date

May 2017

Volume

42

Issue

5

Start / End Page

e227 / e234

Location

United States

Related Subject Headings

  • Survival Analysis
  • Radiopharmaceuticals
  • Predictive Value of Tests
  • Positron Emission Tomography Computed Tomography
  • Oropharyngeal Neoplasms
  • Nuclear Medicine & Medical Imaging
  • Middle Aged
  • Male
  • Humans
  • Fluorodeoxyglucose F18