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Genomic alterations in human epidermal growth factor receptor 2 (HER2/ERBB2) in head and neck squamous cell carcinoma.

Publication ,  Journal Article
Chung, CH; Germain, A; Subramaniam, RM; Heilmann, AM; Fedorchak, K; Ali, SM; Miller, VA; Palermo, RA; Fakhry, C
Published in: Head Neck
January 2017

BACKGROUND: Despite recent advances, survival outcomes for those with metastatic or recurrent head and neck squamous cell carcinoma (HNSCC) have remained poor. Novel approaches should be investigated to improve outcomes. METHODS: A retrospective chart review was performed of a patient who presented with a TNM classification III HNSCC of the oropharynx, positive for human papillomavirus (HPV) who had a complete response to a human epidermal growth factor receptor 2 (HER2)-targeted therapy. Amplification rates of HER2 in the HNSCC Cancer Genome Atlas Network (TCGA) dataset and the FoundationOne genomic profiling dataset were evaluated. RESULTS: Comprehensive genomic profiling of the tumor obtained from the dermal metastasis identified amplification of HER2. Data from TCGA and FoundationOne showed that the frequency of HER2 alteration was not observed to vary significantly with HPV tumor status. CONCLUSION: This case demonstrates the application of genomic profiling to guide treatments in a patient with HNSCC with advanced metastatic disease refractory to standard of care therapies. © 2016 Wiley Periodicals, Inc. Head Neck 39: E15-E19, 2017.

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Published In

Head Neck

DOI

EISSN

1097-0347

Publication Date

January 2017

Volume

39

Issue

1

Start / End Page

E15 / E19

Location

United States

Related Subject Headings

  • Receptor, erbB-2
  • Receptor, ErbB-2
  • Otorhinolaryngology
  • Oropharyngeal Neoplasms
  • Middle Aged
  • Male
  • Humans
  • Carcinoma, Squamous Cell
  • 3203 Dentistry
  • 3202 Clinical sciences
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Chung, C. H., Germain, A., Subramaniam, R. M., Heilmann, A. M., Fedorchak, K., Ali, S. M., … Fakhry, C. (2017). Genomic alterations in human epidermal growth factor receptor 2 (HER2/ERBB2) in head and neck squamous cell carcinoma. Head Neck, 39(1), E15–E19. https://doi.org/10.1002/hed.24587
Chung, Christine H., Alexis Germain, Rathan M. Subramaniam, Andreas M. Heilmann, Kyle Fedorchak, Siraj M. Ali, Vincent A. Miller, Robert A. Palermo, and Carole Fakhry. “Genomic alterations in human epidermal growth factor receptor 2 (HER2/ERBB2) in head and neck squamous cell carcinoma.Head Neck 39, no. 1 (January 2017): E15–19. https://doi.org/10.1002/hed.24587.
Chung CH, Germain A, Subramaniam RM, Heilmann AM, Fedorchak K, Ali SM, et al. Genomic alterations in human epidermal growth factor receptor 2 (HER2/ERBB2) in head and neck squamous cell carcinoma. Head Neck. 2017 Jan;39(1):E15–9.
Chung, Christine H., et al. “Genomic alterations in human epidermal growth factor receptor 2 (HER2/ERBB2) in head and neck squamous cell carcinoma.Head Neck, vol. 39, no. 1, Jan. 2017, pp. E15–19. Pubmed, doi:10.1002/hed.24587.
Chung CH, Germain A, Subramaniam RM, Heilmann AM, Fedorchak K, Ali SM, Miller VA, Palermo RA, Fakhry C. Genomic alterations in human epidermal growth factor receptor 2 (HER2/ERBB2) in head and neck squamous cell carcinoma. Head Neck. 2017 Jan;39(1):E15–E19.
Journal cover image

Published In

Head Neck

DOI

EISSN

1097-0347

Publication Date

January 2017

Volume

39

Issue

1

Start / End Page

E15 / E19

Location

United States

Related Subject Headings

  • Receptor, erbB-2
  • Receptor, ErbB-2
  • Otorhinolaryngology
  • Oropharyngeal Neoplasms
  • Middle Aged
  • Male
  • Humans
  • Carcinoma, Squamous Cell
  • 3203 Dentistry
  • 3202 Clinical sciences