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Impact of Diuretic Therapy in the Treatment of Bronchopulmonary Dysplasia and Acute Kidney Injury in the Neonatal Population.

Publication ,  Journal Article
Johnson, AK; Lynch, N; Newberry, D; Jnah, AJ
Published in: Advances in neonatal care : official journal of the National Association of Neonatal Nurses
October 2017

Diuretics are among the most frequently prescribed medications in the neonatal intensive care unit (NICU), despite minimal data regarding the safety and efficacy of their use in the neonatal population. Off-label diuretic therapy is used in preterm and full-term infants to both optimize kidney function and improve respiratory status.This article examines the literature specific to the impact of diuretic therapy in the NICU and compares the benefits versus risks of utilization as they pertain to the prevention and treatment of renal and pulmonary dysfunction in this population.A comprehensive literature search of online databases was performed, utilizing: CINAHL via EBSCO, PubMed, and ProQuest. Full-text, peer-reviewed, clinical trials, and review articles published in the English language between 2005 and 2015 were searched.Diuretics rank as the seventh most frequently prescribed medication in the NICU. More than 8% of all NICU patients and 37% of infants born at less than 32 gestational weeks and weighing less than 1500 g are exposed to diuretics. Benefits include lung fluid resorption acceleration, improved urine output, fluid retention counteraction, and augmentation of physiologic weight loss.Diuretics are currently utilized in the NICU at an alarming rate, without adequate clinical trials regarding their safety and efficacy of use.Updated studies are needed regarding short- and long-term outcomes of diuretic use, as well as overall general outcome data regarding the impact and evaluation of diuretic usage in the NICU population.

Duke Scholars

Published In

Advances in neonatal care : official journal of the National Association of Neonatal Nurses

DOI

EISSN

1536-0911

ISSN

1536-0903

Publication Date

October 2017

Volume

17

Issue

5

Start / End Page

337 / 346

Related Subject Headings

  • Pediatrics
  • Off-Label Use
  • Intensive Care Units, Neonatal
  • Infant, Premature
  • Infant, Newborn
  • Humans
  • Evidence-Based Medicine
  • Diuretics
  • Bronchopulmonary Dysplasia
  • Acute Kidney Injury
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Johnson, A. K., Lynch, N., Newberry, D., & Jnah, A. J. (2017). Impact of Diuretic Therapy in the Treatment of Bronchopulmonary Dysplasia and Acute Kidney Injury in the Neonatal Population. Advances in Neonatal Care : Official Journal of the National Association of Neonatal Nurses, 17(5), 337–346. https://doi.org/10.1097/anc.0000000000000427
Johnson, Alexandra Kesler, Natalie Lynch, Desi Newberry, and Amy J. Jnah. “Impact of Diuretic Therapy in the Treatment of Bronchopulmonary Dysplasia and Acute Kidney Injury in the Neonatal Population.Advances in Neonatal Care : Official Journal of the National Association of Neonatal Nurses 17, no. 5 (October 2017): 337–46. https://doi.org/10.1097/anc.0000000000000427.
Johnson AK, Lynch N, Newberry D, Jnah AJ. Impact of Diuretic Therapy in the Treatment of Bronchopulmonary Dysplasia and Acute Kidney Injury in the Neonatal Population. Advances in neonatal care : official journal of the National Association of Neonatal Nurses. 2017 Oct;17(5):337–46.
Johnson, Alexandra Kesler, et al. “Impact of Diuretic Therapy in the Treatment of Bronchopulmonary Dysplasia and Acute Kidney Injury in the Neonatal Population.Advances in Neonatal Care : Official Journal of the National Association of Neonatal Nurses, vol. 17, no. 5, Oct. 2017, pp. 337–46. Epmc, doi:10.1097/anc.0000000000000427.
Johnson AK, Lynch N, Newberry D, Jnah AJ. Impact of Diuretic Therapy in the Treatment of Bronchopulmonary Dysplasia and Acute Kidney Injury in the Neonatal Population. Advances in neonatal care : official journal of the National Association of Neonatal Nurses. 2017 Oct;17(5):337–346.

Published In

Advances in neonatal care : official journal of the National Association of Neonatal Nurses

DOI

EISSN

1536-0911

ISSN

1536-0903

Publication Date

October 2017

Volume

17

Issue

5

Start / End Page

337 / 346

Related Subject Headings

  • Pediatrics
  • Off-Label Use
  • Intensive Care Units, Neonatal
  • Infant, Premature
  • Infant, Newborn
  • Humans
  • Evidence-Based Medicine
  • Diuretics
  • Bronchopulmonary Dysplasia
  • Acute Kidney Injury