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OPMI: The ontology of precision medicine and investigation and its support for clinical data and metadata representation and analysis

Publication ,  Conference
He, Y; Ong, E; Schaub, J; Dowd, F; O'Toole, JF; Siapos, A; Reich, C; Seager, S; Wan, L; Yu, H; Zheng, J; Stoeckert, C; Yang, X; Yang, S ...
Published in: CEUR Workshop Proceedings
January 1, 2019

Consortia conducting precision medicine studies face a major challenge of integrating big data including clinical and biomedical data. In this study, we report our development of the community-driven Ontology of Precision Medicine and Investigation (OPMI) and its applications in clinical data and metadata representation. OPMI has been used to represent the common data model (CDM) of the Observational Health Data Sciences and Informatics (or OHDSI) program. It has also been used to represent approximately 30 case report forms defined by the NIH-supported Kidney Precision Medicine Project (KPMP). Our case studies showed that OPMI is able to semantically and precisely represent the OHDSI CDM, various KPMP clinical forms, and their associated data and metadata. Such ontological representations support standardized data representation, sharing, recording, integration, and advanced analysis.

Duke Scholars

Published In

CEUR Workshop Proceedings

ISSN

1613-0073

Publication Date

January 1, 2019

Volume

2931

Related Subject Headings

  • 4609 Information systems
 

Citation

APA
Chicago
ICMJE
MLA
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He, Y., Ong, E., Schaub, J., Dowd, F., O’Toole, J. F., Siapos, A., … Mooney, S. D. (2019). OPMI: The ontology of precision medicine and investigation and its support for clinical data and metadata representation and analysis. In CEUR Workshop Proceedings (Vol. 2931).
He, Y., E. Ong, J. Schaub, F. Dowd, J. F. O’Toole, A. Siapos, C. Reich, et al. “OPMI: The ontology of precision medicine and investigation and its support for clinical data and metadata representation and analysis.” In CEUR Workshop Proceedings, Vol. 2931, 2019.
He Y, Ong E, Schaub J, Dowd F, O’Toole JF, Siapos A, et al. OPMI: The ontology of precision medicine and investigation and its support for clinical data and metadata representation and analysis. In: CEUR Workshop Proceedings. 2019.
He Y, Ong E, Schaub J, Dowd F, O’Toole JF, Siapos A, Reich C, Seager S, Wan L, Yu H, Zheng J, Stoeckert C, Yang X, Yang S, Steck B, Park C, Barisoni L, Kretzler M, Himmelfarb J, Iyengar R, Mooney SD. OPMI: The ontology of precision medicine and investigation and its support for clinical data and metadata representation and analysis. CEUR Workshop Proceedings. 2019.

Published In

CEUR Workshop Proceedings

ISSN

1613-0073

Publication Date

January 1, 2019

Volume

2931

Related Subject Headings

  • 4609 Information systems