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Effects of Vitamin D Supplementation on Insulin Sensitivity and Secretion in Prediabetes.

Publication ,  Journal Article
Rasouli, N; Brodsky, IG; Chatterjee, R; Kim, SH; Pratley, RE; Staten, MA; Pittas, AG; D2d Research Group
Published in: J Clin Endocrinol Metab
January 1, 2022

CONTEXT: Vitamin D regulates glucose homeostasis pathways, but effects of vitamin D supplementation on β-cell function remain unclear. OBJECTIVE: To investigate the effects of vitamin D3 supplementation on insulin sensitivity and β-cell function. METHODS: This is a prespecified secondary analysis of the Vitamin D and Type 2 Diabetes study. Overweight/obese adults at high risk for type 2 diabetes (prediabetes) were randomly treated with vitamin D3 4000 IU or matching placebo daily for 24 months. MAIN OUTCOME: Disposition index (DI), as an estimate of β-cell function, was calculated as the product of Homeostasis Model Assessment 2 indices derived from C-peptide values (HOMA2%Scpep) and C-peptide response during the first 30 minutes of a 75-g oral glucose tolerance test (OGTT). RESULTS: Mean age was 60.5 ± 9.8 years and body mass index was 31.9 ± 4.4 kg/m2. Mean serum 25(OH)D level increased from 27.9 ± 10.3 ng/mL at baseline to 54.9 ng/mL at 2 years in the vitamin D group and was unchanged (28.5 ± 10.0 ng/mL) in the placebo group. The baseline DI predicted incident diabetes independent of the intervention. In the entire cohort, there were no significant differences in changes in DI, HOMA2%Scpep, or C-peptide response between the 2 groups. Among participants with baseline 25(OH)D level <12 ng/mL, the mean percent differences for DI between the vitamin D and placebo groups was 8.5 (95% CI, 0.2-16.8). CONCLUSIONS: Supplementation with vitamin D3 for 24 months did not improve an OGTT-derived index of β-cell function in people with prediabetes not selected based on baseline vitamin D status; however, there was benefit among those with very low baseline vitamin D status.

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Published In

J Clin Endocrinol Metab

DOI

EISSN

1945-7197

Publication Date

January 1, 2022

Volume

107

Issue

1

Start / End Page

230 / 240

Location

United States

Related Subject Headings

  • Vitamin D Deficiency
  • Vitamin D
  • Treatment Outcome
  • Prediabetic State
  • Overweight
  • Middle Aged
  • Male
  • Insulin-Secreting Cells
  • Insulin Resistance
  • Insulin
 

Citation

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Rasouli, N., Brodsky, I. G., Chatterjee, R., Kim, S. H., Pratley, R. E., Staten, M. A., … D2d Research Group. (2022). Effects of Vitamin D Supplementation on Insulin Sensitivity and Secretion in Prediabetes. J Clin Endocrinol Metab, 107(1), 230–240. https://doi.org/10.1210/clinem/dgab649
Rasouli, Neda, Irwin G. Brodsky, Ranee Chatterjee, Sun H. Kim, Richard E. Pratley, Myrlene A. Staten, Anastassios G. Pittas, and D2d Research Group. “Effects of Vitamin D Supplementation on Insulin Sensitivity and Secretion in Prediabetes.J Clin Endocrinol Metab 107, no. 1 (January 1, 2022): 230–40. https://doi.org/10.1210/clinem/dgab649.
Rasouli N, Brodsky IG, Chatterjee R, Kim SH, Pratley RE, Staten MA, et al. Effects of Vitamin D Supplementation on Insulin Sensitivity and Secretion in Prediabetes. J Clin Endocrinol Metab. 2022 Jan 1;107(1):230–40.
Rasouli, Neda, et al. “Effects of Vitamin D Supplementation on Insulin Sensitivity and Secretion in Prediabetes.J Clin Endocrinol Metab, vol. 107, no. 1, Jan. 2022, pp. 230–40. Pubmed, doi:10.1210/clinem/dgab649.
Rasouli N, Brodsky IG, Chatterjee R, Kim SH, Pratley RE, Staten MA, Pittas AG, D2d Research Group. Effects of Vitamin D Supplementation on Insulin Sensitivity and Secretion in Prediabetes. J Clin Endocrinol Metab. 2022 Jan 1;107(1):230–240.
Journal cover image

Published In

J Clin Endocrinol Metab

DOI

EISSN

1945-7197

Publication Date

January 1, 2022

Volume

107

Issue

1

Start / End Page

230 / 240

Location

United States

Related Subject Headings

  • Vitamin D Deficiency
  • Vitamin D
  • Treatment Outcome
  • Prediabetic State
  • Overweight
  • Middle Aged
  • Male
  • Insulin-Secreting Cells
  • Insulin Resistance
  • Insulin