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A Modern-World View of Host-Microbiota-Pathogen Interactions.

Publication ,  Journal Article
Tan, CY; Ramirez, ZE; Surana, NK
Published in: Journal of immunology (Baltimore, Md. : 1950)
October 2021

The microbiota-the diverse set of commensal microbes that normally colonize humans-represents the first line of defense against infectious diseases. In this review, we summarize the direct and indirect mechanisms by which the microbiota modulates susceptibility to, and severity of, infections, with a focus on immunological mechanisms. Moreover, we highlight some of the ways that modern-world lifestyles have influenced the structure-function relationship between the microbiota and infectious diseases. Ultimately, understanding how the microbiota influences infectious risks will facilitate development of microbiota-derived therapeutics that bolster host defenses.

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Published In

Journal of immunology (Baltimore, Md. : 1950)

DOI

EISSN

1550-6606

ISSN

0022-1767

Publication Date

October 2021

Volume

207

Issue

7

Start / End Page

1710 / 1718

Related Subject Headings

  • Structure-Activity Relationship
  • Microbiota
  • Infections
  • Immunology
  • Immunity, Innate
  • Humans
  • Host-Pathogen Interactions
  • Host Microbial Interactions
  • Disease Susceptibility
  • Biological Therapy
 

Citation

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Tan, C. Y., Ramirez, Z. E., & Surana, N. K. (2021). A Modern-World View of Host-Microbiota-Pathogen Interactions. Journal of Immunology (Baltimore, Md. : 1950), 207(7), 1710–1718. https://doi.org/10.4049/jimmunol.2100215
Tan, Chin Yee, Zeni E. Ramirez, and Neeraj K. Surana. “A Modern-World View of Host-Microbiota-Pathogen Interactions.Journal of Immunology (Baltimore, Md. : 1950) 207, no. 7 (October 2021): 1710–18. https://doi.org/10.4049/jimmunol.2100215.
Tan CY, Ramirez ZE, Surana NK. A Modern-World View of Host-Microbiota-Pathogen Interactions. Journal of immunology (Baltimore, Md : 1950). 2021 Oct;207(7):1710–8.
Tan, Chin Yee, et al. “A Modern-World View of Host-Microbiota-Pathogen Interactions.Journal of Immunology (Baltimore, Md. : 1950), vol. 207, no. 7, Oct. 2021, pp. 1710–18. Epmc, doi:10.4049/jimmunol.2100215.
Tan CY, Ramirez ZE, Surana NK. A Modern-World View of Host-Microbiota-Pathogen Interactions. Journal of immunology (Baltimore, Md : 1950). 2021 Oct;207(7):1710–1718.

Published In

Journal of immunology (Baltimore, Md. : 1950)

DOI

EISSN

1550-6606

ISSN

0022-1767

Publication Date

October 2021

Volume

207

Issue

7

Start / End Page

1710 / 1718

Related Subject Headings

  • Structure-Activity Relationship
  • Microbiota
  • Infections
  • Immunology
  • Immunity, Innate
  • Humans
  • Host-Pathogen Interactions
  • Host Microbial Interactions
  • Disease Susceptibility
  • Biological Therapy