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Dissociable components of rule-guided behavior depend on distinct medial and prefrontal regions.

Publication ,  Journal Article
Buckley, MJ; Mansouri, FA; Hoda, H; Mahboubi, M; Browning, PGF; Kwok, SC; Phillips, A; Tanaka, K
Published in: Science (New York, N.Y.)
July 2009

Much of our behavior is guided by rules. Although human prefrontal cortex (PFC) and anterior cingulate cortex (ACC) are implicated in implementing rule-guided behavior, the crucial contributions made by different regions within these areas are not yet specified. In an attempt to bridge human neuropsychology and nonhuman primate neurophysiology, we report the effects of circumscribed lesions to macaque orbitofrontal cortex (OFC), principal sulcus (PS), superior dorsolateral PFC, ventrolateral PFC, or ACC sulcus, on separable cognitive components of a Wisconsin Card Sorting Test (WCST) analog. Only the PS lesions impaired maintenance of abstract rules in working memory; only the OFC lesions impaired rapid reward-based updating of representations of rule value; the ACC sulcus lesions impaired active reference to the value of recent choice-outcomes during rule-based decision-making.

Duke Scholars

Published In

Science (New York, N.Y.)

DOI

EISSN

1095-9203

ISSN

0036-8075

Publication Date

July 2009

Volume

325

Issue

5936

Start / End Page

52 / 58

Related Subject Headings

  • Reward
  • Reinforcement, Psychology
  • Prefrontal Cortex
  • Neuropsychological Tests
  • Neurons
  • Memory, Short-Term
  • Macaca mulatta
  • Macaca
  • Learning
  • General Science & Technology
 

Citation

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ICMJE
MLA
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Buckley, M. J., Mansouri, F. A., Hoda, H., Mahboubi, M., Browning, P. G. F., Kwok, S. C., … Tanaka, K. (2009). Dissociable components of rule-guided behavior depend on distinct medial and prefrontal regions. Science (New York, N.Y.), 325(5936), 52–58. https://doi.org/10.1126/science.1172377
Buckley, Mark J., Farshad A. Mansouri, Hassan Hoda, Majid Mahboubi, Philip G. F. Browning, Sze C. Kwok, Adam Phillips, and Keiji Tanaka. “Dissociable components of rule-guided behavior depend on distinct medial and prefrontal regions.Science (New York, N.Y.) 325, no. 5936 (July 2009): 52–58. https://doi.org/10.1126/science.1172377.
Buckley MJ, Mansouri FA, Hoda H, Mahboubi M, Browning PGF, Kwok SC, et al. Dissociable components of rule-guided behavior depend on distinct medial and prefrontal regions. Science (New York, NY). 2009 Jul;325(5936):52–8.
Buckley, Mark J., et al. “Dissociable components of rule-guided behavior depend on distinct medial and prefrontal regions.Science (New York, N.Y.), vol. 325, no. 5936, July 2009, pp. 52–58. Epmc, doi:10.1126/science.1172377.
Buckley MJ, Mansouri FA, Hoda H, Mahboubi M, Browning PGF, Kwok SC, Phillips A, Tanaka K. Dissociable components of rule-guided behavior depend on distinct medial and prefrontal regions. Science (New York, NY). 2009 Jul;325(5936):52–58.
Journal cover image

Published In

Science (New York, N.Y.)

DOI

EISSN

1095-9203

ISSN

0036-8075

Publication Date

July 2009

Volume

325

Issue

5936

Start / End Page

52 / 58

Related Subject Headings

  • Reward
  • Reinforcement, Psychology
  • Prefrontal Cortex
  • Neuropsychological Tests
  • Neurons
  • Memory, Short-Term
  • Macaca mulatta
  • Macaca
  • Learning
  • General Science & Technology