Scholars@Duke publication: Rational design of a trimeric APRIL-based CAR-binding domain enables efficient targeting of multiple myeloma

Rational design of a trimeric APRIL-based CAR-binding domain enables efficient targeting of multiple myeloma

Publication , Journal Article

Schmidts, A; Ormhøj, M; Choi, BD; Taylor, AO; Bouffard, AA; Scarfò, I; Larson, RC; Frigault, MJ; Gallagher, K; Castano, AP; Riley, LS; Zhou, J ...

Published in: Blood Advances

November 12, 2019

Published version (DOI) Publisher Link

A trimeric extracellular moiety of APRIL has enhanced binding to BCMA and TACI compared with monomeric APRIL when incorporated into a CAR. T cells transduced with a trimeric APRIL-based CAR are a promising approach for the treatment of MM.

Duke Scholars

Author Allison Taylor

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Published In

Blood Advances

DOI

10.1182/bloodadvances.2019000703

EISSN

2473-9537

ISSN

2473-9529

Publication Date

November 12, 2019

Volume

Issue

Start / End Page

3248 / 3260

Publisher

American Society of Hematology

Citation

APA

Chicago

ICMJE

MLA

NLM

Schmidts, A., Ormhøj, M., Choi, B. D., Taylor, A. O., Bouffard, A. A., Scarfò, I., … Maus, M. V. (2019). Rational design of a trimeric APRIL-based CAR-binding domain enables efficient targeting of multiple myeloma. Blood Advances, 3(21), 3248–3260. https://doi.org/10.1182/bloodadvances.2019000703

Schmidts, Andrea, Maria Ormhøj, Bryan D. Choi, Allison O. Taylor, Amanda A. Bouffard, Irene Scarfò, Rebecca C. Larson, et al. “Rational design of a trimeric APRIL-based CAR-binding domain enables efficient targeting of multiple myeloma.” Blood Advances 3, no. 21 (November 12, 2019): 3248–60. https://doi.org/10.1182/bloodadvances.2019000703.

Schmidts A, Ormhøj M, Choi BD, Taylor AO, Bouffard AA, Scarfò I, et al. Rational design of a trimeric APRIL-based CAR-binding domain enables efficient targeting of multiple myeloma. Blood Advances. 2019 Nov 12;3(21):3248–60.

Schmidts, Andrea, et al. “Rational design of a trimeric APRIL-based CAR-binding domain enables efficient targeting of multiple myeloma.” Blood Advances, vol. 3, no. 21, American Society of Hematology, Nov. 2019, pp. 3248–60. Crossref, doi:10.1182/bloodadvances.2019000703.

Schmidts A, Ormhøj M, Choi BD, Taylor AO, Bouffard AA, Scarfò I, Larson RC, Frigault MJ, Gallagher K, Castano AP, Riley LS, Cabral ML, Boroughs AC, Velasco Cárdenas RM-H, Schamel W, Zhou J, Mackay S, Tai Y-T, Anderson KC, Maus MV. Rational design of a trimeric APRIL-based CAR-binding domain enables efficient targeting of multiple myeloma. Blood Advances. American Society of Hematology; 2019 Nov 12;3(21):3248–3260.

Published In

Blood Advances

DOI

10.1182/bloodadvances.2019000703

EISSN

2473-9537

ISSN

2473-9529

Publication Date

November 12, 2019

Volume

Issue

Start / End Page

3248 / 3260

Publisher

American Society of Hematology