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Obesity before age 30 years and risk of advanced prostate cancer.

Publication ,  Journal Article
Robinson, WR; Stevens, J; Gammon, MD; John, EM
Published in: Am J Epidemiol
June 15, 2005

Adult obesity has shown little association with prostate cancer risk, but obesity at younger ages may be associated with reduced risk. In 1997-2000, the relation between obesity before age 30 years and incident advanced prostate cancer was investigated in a population-based case-control study of African-American and White men (568 cases, 544 controls) in California. Unconditional logistic regression was used to estimate odds ratios and 95% confidence intervals, adjusted for age, race, family history of prostate cancer, and saturated fat intake. Measures of obesity for age 10 years tended to be inversely associated with prostate cancer (odds ratio (OR) = 0.79, 95% confidence interval (CI): 0.46, 1.38 for selecting the "obese" pictogram and OR = 0.76, 95% CI: 0.52, 1.11 for reporting being heavier than peers). The decreased risk was more pronounced at ages 20-29 years (OR = 0.53, 95% CI: 0.28, 1.00 for the "obese" drawing, OR = 0.59, 95% CI: 0.40, 0.88 for being heavier than peers, and OR = 0.40, 95% CI: 0.20, 0.81 for body mass index > or =30 kg/m(2)). In addition, both "obese" and small waist size at ages 20-29 years showed inverse trends. This research implicating early-life body size in prostate cancer development helps to elucidate causal mechanisms, such as altered sex hormone profiles during critical developmental periods, potentially involved in development of the disease.

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Published In

Am J Epidemiol

DOI

ISSN

0002-9262

Publication Date

June 15, 2005

Volume

161

Issue

12

Start / End Page

1107 / 1114

Location

United States

Related Subject Headings

  • White People
  • Socioeconomic Factors
  • Risk Factors
  • Prostatic Neoplasms
  • Odds Ratio
  • Obesity
  • Middle Aged
  • Male
  • Humans
  • Epidemiology
 

Citation

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Robinson, W. R., Stevens, J., Gammon, M. D., & John, E. M. (2005). Obesity before age 30 years and risk of advanced prostate cancer. Am J Epidemiol, 161(12), 1107–1114. https://doi.org/10.1093/aje/kwi150
Robinson, Whitney R., June Stevens, Marilie D. Gammon, and Esther M. John. “Obesity before age 30 years and risk of advanced prostate cancer.Am J Epidemiol 161, no. 12 (June 15, 2005): 1107–14. https://doi.org/10.1093/aje/kwi150.
Robinson WR, Stevens J, Gammon MD, John EM. Obesity before age 30 years and risk of advanced prostate cancer. Am J Epidemiol. 2005 Jun 15;161(12):1107–14.
Robinson, Whitney R., et al. “Obesity before age 30 years and risk of advanced prostate cancer.Am J Epidemiol, vol. 161, no. 12, June 2005, pp. 1107–14. Pubmed, doi:10.1093/aje/kwi150.
Robinson WR, Stevens J, Gammon MD, John EM. Obesity before age 30 years and risk of advanced prostate cancer. Am J Epidemiol. 2005 Jun 15;161(12):1107–1114.
Journal cover image

Published In

Am J Epidemiol

DOI

ISSN

0002-9262

Publication Date

June 15, 2005

Volume

161

Issue

12

Start / End Page

1107 / 1114

Location

United States

Related Subject Headings

  • White People
  • Socioeconomic Factors
  • Risk Factors
  • Prostatic Neoplasms
  • Odds Ratio
  • Obesity
  • Middle Aged
  • Male
  • Humans
  • Epidemiology