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DNA Damage Responses during the Cell Cycle: Insights from Model Organisms and Beyond.

Publication ,  Journal Article
Clay, DE; Fox, DT
Published in: Genes (Basel)
November 25, 2021

Genome damage is a threat to all organisms. To respond to such damage, DNA damage responses (DDRs) lead to cell cycle arrest, DNA repair, and cell death. Many DDR components are highly conserved, whereas others have adapted to specific organismal needs. Immense progress in this field has been driven by model genetic organism research. This review has two main purposes. First, we provide a survey of model organism-based efforts to study DDRs. Second, we highlight how model organism study has contributed to understanding how specific DDRs are influenced by cell cycle stage. We also look forward, with a discussion of how future study can be expanded beyond typical model genetic organisms to further illuminate how the genome is protected.

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Published In

Genes (Basel)

DOI

EISSN

2073-4425

Publication Date

November 25, 2021

Volume

12

Issue

12

Location

Switzerland

Related Subject Headings

  • Signal Transduction
  • Humans
  • DNA Repair
  • DNA Damage
  • Cell Cycle Checkpoints
  • Cell Cycle
  • Animals
  • 3105 Genetics
  • 0604 Genetics
 

Citation

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ICMJE
MLA
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Clay, D. E., & Fox, D. T. (2021). DNA Damage Responses during the Cell Cycle: Insights from Model Organisms and Beyond. Genes (Basel), 12(12). https://doi.org/10.3390/genes12121882
Clay, Delisa E., and Donald T. Fox. “DNA Damage Responses during the Cell Cycle: Insights from Model Organisms and Beyond.Genes (Basel) 12, no. 12 (November 25, 2021). https://doi.org/10.3390/genes12121882.
Clay, Delisa E., and Donald T. Fox. “DNA Damage Responses during the Cell Cycle: Insights from Model Organisms and Beyond.Genes (Basel), vol. 12, no. 12, Nov. 2021. Pubmed, doi:10.3390/genes12121882.

Published In

Genes (Basel)

DOI

EISSN

2073-4425

Publication Date

November 25, 2021

Volume

12

Issue

12

Location

Switzerland

Related Subject Headings

  • Signal Transduction
  • Humans
  • DNA Repair
  • DNA Damage
  • Cell Cycle Checkpoints
  • Cell Cycle
  • Animals
  • 3105 Genetics
  • 0604 Genetics