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Is There a Role for Immunotherapy in Central Nervous System Cancers?

Publication ,  Journal Article
Flores, C; Dunn, G; Fecci, P; Lim, M; Mitchell, D; Reardon, DA
Published in: Hematol Oncol Clin North Am
February 2022

Glioblastoma has emerged as an immunotherapy-refractory tumor based on negative phase III studies of anti-programmed cell death-1 therapy among newly diagnosed as well as recurrent patients. In addition, although much work on vaccine and cellular approaches is ongoing, therapeutic benefit with these approaches has been underwhelming. Much scientific insight into the multitiered layers of immunosuppression exploited by glioblastoma tumors is emerging that sheds light on the explanation for the disappointing results to date and highlights possible therapeutic avenues that may offer a better likelihood of therapeutic benefit for immune-based therapies.

Duke Scholars

Published In

Hematol Oncol Clin North Am

DOI

EISSN

1558-1977

Publication Date

February 2022

Volume

36

Issue

1

Start / End Page

237 / 252

Location

United States

Related Subject Headings

  • Oncology & Carcinogenesis
  • Neoplasm Recurrence, Local
  • Immunotherapy
  • Humans
  • Glioblastoma
  • Central Nervous System Neoplasms
  • Central Nervous System
  • Cancer Vaccines
  • Brain Neoplasms
  • 1102 Cardiorespiratory Medicine and Haematology
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Flores, C., Dunn, G., Fecci, P., Lim, M., Mitchell, D., & Reardon, D. A. (2022). Is There a Role for Immunotherapy in Central Nervous System Cancers? Hematol Oncol Clin North Am, 36(1), 237–252. https://doi.org/10.1016/j.hoc.2021.09.002
Flores, Catherine, Gavin Dunn, Peter Fecci, Michael Lim, Duane Mitchell, and David A. Reardon. “Is There a Role for Immunotherapy in Central Nervous System Cancers?Hematol Oncol Clin North Am 36, no. 1 (February 2022): 237–52. https://doi.org/10.1016/j.hoc.2021.09.002.
Flores C, Dunn G, Fecci P, Lim M, Mitchell D, Reardon DA. Is There a Role for Immunotherapy in Central Nervous System Cancers? Hematol Oncol Clin North Am. 2022 Feb;36(1):237–52.
Flores, Catherine, et al. “Is There a Role for Immunotherapy in Central Nervous System Cancers?Hematol Oncol Clin North Am, vol. 36, no. 1, Feb. 2022, pp. 237–52. Pubmed, doi:10.1016/j.hoc.2021.09.002.
Flores C, Dunn G, Fecci P, Lim M, Mitchell D, Reardon DA. Is There a Role for Immunotherapy in Central Nervous System Cancers? Hematol Oncol Clin North Am. 2022 Feb;36(1):237–252.
Journal cover image

Published In

Hematol Oncol Clin North Am

DOI

EISSN

1558-1977

Publication Date

February 2022

Volume

36

Issue

1

Start / End Page

237 / 252

Location

United States

Related Subject Headings

  • Oncology & Carcinogenesis
  • Neoplasm Recurrence, Local
  • Immunotherapy
  • Humans
  • Glioblastoma
  • Central Nervous System Neoplasms
  • Central Nervous System
  • Cancer Vaccines
  • Brain Neoplasms
  • 1102 Cardiorespiratory Medicine and Haematology