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Predictors of Plasmodium falciparum Infection in the First Trimester Among Nulliparous Women From Kenya, Zambia, and the Democratic Republic of the Congo.

Publication ,  Journal Article
Leuba, SI; Westreich, D; Bose, CL; Powers, KA; Olshan, A; Taylor, SM; Tshefu, A; Lokangaka, A; Carlo, WA; Chomba, E; Liechty, EA; Bucher, SL ...
Published in: J Infect Dis
June 1, 2022

BACKGROUND: Malaria can have deleterious effects early in pregnancy, during placentation. However, malaria testing and treatment are rarely initiated until the second trimester, leaving pregnancies unprotected in the first trimester. To inform potential early intervention approaches, we sought to identify clinical and demographic predictors of first-trimester malaria. METHODS: We prospectively recruited women from sites in the Democratic Republic of the Congo (DRC), Kenya, and Zambia who participated in the ASPIRIN (Aspirin Supplementation for Pregnancy Indicated risk Reduction In Nulliparas) trial. Nulliparous women were tested for first-trimester Plasmodium falciparum infection by quantitative polymerase chain reaction. We evaluated predictors using descriptive statistics. RESULTS: First-trimester malaria prevalence among 1513 nulliparous pregnant women was 6.3% (95% confidence interval [CI], 3.7%-8.8%] in the Zambian site, 37.8% (95% CI, 34.2%-41.5%) in the Kenyan site, and 62.9% (95% CI, 58.6%-67.2%) in the DRC site. First-trimester malaria was associated with shorter height and younger age in Kenyan women in site-stratified analyses, and with lower educational attainment in analyses combining all 3 sites. No other predictors were identified. CONCLUSIONS: First-trimester malaria prevalence varied by study site in sub-Saharan Africa. The absence of consistent predictors suggests that routine parasite screening in early pregnancy may be needed to mitigate first-trimester malaria in high-prevalence settings.

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Published In

J Infect Dis

DOI

EISSN

1537-6613

Publication Date

June 1, 2022

Volume

225

Issue

11

Start / End Page

2002 / 2010

Location

United States

Related Subject Headings

  • Zambia
  • Prevalence
  • Pregnancy Trimester, First
  • Pregnancy
  • Plasmodium falciparum
  • Microbiology
  • Malaria, Falciparum
  • Malaria
  • Kenya
  • Humans
 

Citation

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Chicago
ICMJE
MLA
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Leuba, S. I., Westreich, D., Bose, C. L., Powers, K. A., Olshan, A., Taylor, S. M., … Bauserman, M. (2022). Predictors of Plasmodium falciparum Infection in the First Trimester Among Nulliparous Women From Kenya, Zambia, and the Democratic Republic of the Congo. J Infect Dis, 225(11), 2002–2010. https://doi.org/10.1093/infdis/jiab588
Leuba, Sequoia I., Daniel Westreich, Carl L. Bose, Kimberly A. Powers, Andy Olshan, Steve M. Taylor, Antoinette Tshefu, et al. “Predictors of Plasmodium falciparum Infection in the First Trimester Among Nulliparous Women From Kenya, Zambia, and the Democratic Republic of the Congo.J Infect Dis 225, no. 11 (June 1, 2022): 2002–10. https://doi.org/10.1093/infdis/jiab588.
Leuba SI, Westreich D, Bose CL, Powers KA, Olshan A, Taylor SM, et al. Predictors of Plasmodium falciparum Infection in the First Trimester Among Nulliparous Women From Kenya, Zambia, and the Democratic Republic of the Congo. J Infect Dis. 2022 Jun 1;225(11):2002–10.
Leuba, Sequoia I., et al. “Predictors of Plasmodium falciparum Infection in the First Trimester Among Nulliparous Women From Kenya, Zambia, and the Democratic Republic of the Congo.J Infect Dis, vol. 225, no. 11, June 2022, pp. 2002–10. Pubmed, doi:10.1093/infdis/jiab588.
Leuba SI, Westreich D, Bose CL, Powers KA, Olshan A, Taylor SM, Tshefu A, Lokangaka A, Carlo WA, Chomba E, Liechty EA, Bucher SL, Esamai F, Jessani S, Saleem S, Goldenberg RL, Moore J, Nolen T, Hemingway-Foday J, McClure EM, Koso-Thomas M, Derman RJ, Hoffman M, Bauserman M. Predictors of Plasmodium falciparum Infection in the First Trimester Among Nulliparous Women From Kenya, Zambia, and the Democratic Republic of the Congo. J Infect Dis. 2022 Jun 1;225(11):2002–2010.
Journal cover image

Published In

J Infect Dis

DOI

EISSN

1537-6613

Publication Date

June 1, 2022

Volume

225

Issue

11

Start / End Page

2002 / 2010

Location

United States

Related Subject Headings

  • Zambia
  • Prevalence
  • Pregnancy Trimester, First
  • Pregnancy
  • Plasmodium falciparum
  • Microbiology
  • Malaria, Falciparum
  • Malaria
  • Kenya
  • Humans