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Hidradenitis Suppurativa: Host-Microbe and Immune Pathogenesis Underlie Important Future Directions.

Publication ,  Journal Article
Jiang, SW; Whitley, MJ; Mariottoni, P; Jaleel, T; MacLeod, AS
Published in: JID Innov
March 2021

Hidradenitis suppurativa (HS) is an inflammatory disease of the skin with a chronic, relapsing-remitting course. The pathogenesis of the disease is poorly understood and involves multiple factors, including genetics, environment, host-microbe interactions, and immune dysregulation. In particular, the composition of the cutaneous microbiome shifts as the disease progresses, although it is unclear whether this is a primary or secondary process. Trials with immunomodulatory therapy elucidate the role of specific immune pathways and cytokine signaling in disease mechanism, such as TNF-α, IL-1β, IL-12, IL-17, IL-23, and complement. Future studies should continue examining the causes of and contributing factors to microbial changes and immune dysregulation in HS pathogenesis.

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Published In

JID Innov

DOI

EISSN

2667-0267

Publication Date

March 2021

Volume

1

Issue

1

Start / End Page

100001

Location

Netherlands
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Jiang, S. W., Whitley, M. J., Mariottoni, P., Jaleel, T., & MacLeod, A. S. (2021). Hidradenitis Suppurativa: Host-Microbe and Immune Pathogenesis Underlie Important Future Directions. JID Innov, 1(1), 100001. https://doi.org/10.1016/j.xjidi.2021.100001
Jiang, Simon W., Melodi Javid Whitley, Paula Mariottoni, Tarannum Jaleel, and Amanda S. MacLeod. “Hidradenitis Suppurativa: Host-Microbe and Immune Pathogenesis Underlie Important Future Directions.JID Innov 1, no. 1 (March 2021): 100001. https://doi.org/10.1016/j.xjidi.2021.100001.
Jiang SW, Whitley MJ, Mariottoni P, Jaleel T, MacLeod AS. Hidradenitis Suppurativa: Host-Microbe and Immune Pathogenesis Underlie Important Future Directions. JID Innov. 2021 Mar;1(1):100001.
Jiang, Simon W., et al. “Hidradenitis Suppurativa: Host-Microbe and Immune Pathogenesis Underlie Important Future Directions.JID Innov, vol. 1, no. 1, Mar. 2021, p. 100001. Pubmed, doi:10.1016/j.xjidi.2021.100001.
Jiang SW, Whitley MJ, Mariottoni P, Jaleel T, MacLeod AS. Hidradenitis Suppurativa: Host-Microbe and Immune Pathogenesis Underlie Important Future Directions. JID Innov. 2021 Mar;1(1):100001.

Published In

JID Innov

DOI

EISSN

2667-0267

Publication Date

March 2021

Volume

1

Issue

1

Start / End Page

100001

Location

Netherlands