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Roles of estrogen in the formation of intracranial aneurysms in ovariectomized female mice.

Publication ,  Journal Article
Tada, Y; Makino, H; Furukawa, H; Shimada, K; Wada, K; Liang, EI; Murakami, S; Kudo, M; Kung, DK; Hasan, DM; Kitazato, KT; Nagahiro, S ...
Published in: Neurosurgery
December 2014

BACKGROUND: Epidemiological studies have indicated that postmenopausal women have a higher incidence of intracranial aneurysms than men in the same age group. OBJECTIVE: To investigate whether estrogen or estrogen receptors (ERs) mediate protective effects against the formation of intracranial aneurysms. METHODS: Intracranial aneurysms were induced in mice by combining a single injection of elastase into the cerebrospinal fluid with deoxycorticosterone acetate salt hypertension. The mice were treated with estrogen (17β-estradiol), an ERα agonist (propyl pyrazole triol), and an ERβ agonist (diarylpropionitrile) with and without a nitric oxide synthase inhibitor. RESULTS: The ovariectomized female mice had a significantly higher incidence of aneurysms than the male mice, which was consistent with findings in previous epidemiological studies. In ovariectomized female mice, an ERβ agonist, but not an ERα agonist or 17β-estradiol, significantly reduced the incidence of aneurysms. The protective effect of the ERβ agonist was absent in the ovariectomized ERβ knockout mice. The protective effect of the ERβ agonist was negated by treatment with a nitric oxide synthase inhibitor. CONCLUSION: The effects of sex, menopause, and estrogen treatment observed in this animal study were consistent with previous epidemiological findings. Stimulation of estrogen receptor-β was protective against the formation of intracranial aneurysms in ovariectomized female mice.

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Published In

Neurosurgery

DOI

EISSN

1524-4040

Publication Date

December 2014

Volume

75

Issue

6

Start / End Page

690 / 695

Location

United States

Related Subject Headings

  • Sex Characteristics
  • Pyrazoles
  • Propionates
  • Phenols
  • Ovariectomy
  • Nitriles
  • Neurology & Neurosurgery
  • Mice, Knockout
  • Mice
  • Male
 

Citation

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Chicago
ICMJE
MLA
NLM
Tada, Y., Makino, H., Furukawa, H., Shimada, K., Wada, K., Liang, E. I., … Hashimoto, T. (2014). Roles of estrogen in the formation of intracranial aneurysms in ovariectomized female mice. Neurosurgery, 75(6), 690–695. https://doi.org/10.1227/NEU.0000000000000528
Tada, Yoshiteru, Hiroshi Makino, Hajime Furukawa, Kenji Shimada, Kosuke Wada, Elena I. Liang, Shoko Murakami, et al. “Roles of estrogen in the formation of intracranial aneurysms in ovariectomized female mice.Neurosurgery 75, no. 6 (December 2014): 690–95. https://doi.org/10.1227/NEU.0000000000000528.
Tada Y, Makino H, Furukawa H, Shimada K, Wada K, Liang EI, et al. Roles of estrogen in the formation of intracranial aneurysms in ovariectomized female mice. Neurosurgery. 2014 Dec;75(6):690–5.
Tada, Yoshiteru, et al. “Roles of estrogen in the formation of intracranial aneurysms in ovariectomized female mice.Neurosurgery, vol. 75, no. 6, Dec. 2014, pp. 690–95. Pubmed, doi:10.1227/NEU.0000000000000528.
Tada Y, Makino H, Furukawa H, Shimada K, Wada K, Liang EI, Murakami S, Kudo M, Kung DK, Hasan DM, Kitazato KT, Nagahiro S, Lawton MT, Hashimoto T. Roles of estrogen in the formation of intracranial aneurysms in ovariectomized female mice. Neurosurgery. 2014 Dec;75(6):690–695.
Journal cover image

Published In

Neurosurgery

DOI

EISSN

1524-4040

Publication Date

December 2014

Volume

75

Issue

6

Start / End Page

690 / 695

Location

United States

Related Subject Headings

  • Sex Characteristics
  • Pyrazoles
  • Propionates
  • Phenols
  • Ovariectomy
  • Nitriles
  • Neurology & Neurosurgery
  • Mice, Knockout
  • Mice
  • Male