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Alcohol consumption and the risk of mortality and myocardial infarction in patients with rheumatoid arthritis.

Publication ,  Journal Article
Smith, ID; Lu, N; Wei, J; Zhang, Y; Choi, HK; Bolster, MB
Published in: Clinical and experimental rheumatology
September 2022

Many studies have found that moderate alcohol consumption is associated with lower risks of mortality and myocardial infarction (MI). Our aim was to examine the potential effects of alcohol on all-cause mortality and MI in rheumatoid arthritis (RA), a risk factor condition.A cohort study (1995-2017) was conducted using medical records of RA patients from The Health Improvement Network in the United Kingdom (UK). Alcohol exposure was divided into non-drinkers, mild (1-7 UK units/week), moderate (8-14 UK units/week), moderate-high (15-21 UK units/week), and high (>21 UK units/week) consumption levels. We calculated hazard ratios (HRs) for the relation of alcohol consumption to all-cause mortality and MI, adjusting for covariates.Of 30,320 RA patients, 5,994 deaths and 1,098 MI cases occurred over 236,188 person-years. Mild-to-moderate alcohol use was associated with lower all-cause mortality in RA patients, including those taking methotrexate. The multivariable HRs (95% CI) for mortality by alcohol use category were non-drinkers 1.0, mild 0.80 (0.75-0.85), moderate 0.74 (0.67-0.82), moderate-high 0.84 (0.72-0.98), and high 0.99 (0.86-1.15). Mild, moderate-high, and high levels of alcohol use were associated with lower risk of MI among RA patients. The HRs MI risk by alcohol use category were non-drinkers 1.0, mild 0.81 (0.70-0.94), moderate 0.84 (0.68-1.04), moderate-high 0.51 (0.35-0.74), and high 0.59 (0.42-0.84).These findings suggest that mild-to-moderate alcohol use is associated with a lower mortality risk and overall alcohol use is associated with a lower MI risk in RA patients, similar to the general population.

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Published In

Clinical and experimental rheumatology

DOI

EISSN

1593-098X

ISSN

0392-856X

Publication Date

September 2022

Volume

40

Issue

9

Start / End Page

1754 / 1761

Related Subject Headings

  • Risk Factors
  • Myocardial Infarction
  • Methotrexate
  • Humans
  • Cohort Studies
  • Arthritis, Rheumatoid
  • Arthritis & Rheumatology
  • Alcohol Drinking
  • 3202 Clinical sciences
  • 1103 Clinical Sciences
 

Citation

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ICMJE
MLA
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Smith, I. D., Lu, N., Wei, J., Zhang, Y., Choi, H. K., & Bolster, M. B. (2022). Alcohol consumption and the risk of mortality and myocardial infarction in patients with rheumatoid arthritis. Clinical and Experimental Rheumatology, 40(9), 1754–1761. https://doi.org/10.55563/clinexprheumatol/8snr4x
Smith, Isaac D., Na Lu, Jie Wei, Yuqing Zhang, Hyon K. Choi, and Marcy B. Bolster. “Alcohol consumption and the risk of mortality and myocardial infarction in patients with rheumatoid arthritis.Clinical and Experimental Rheumatology 40, no. 9 (September 2022): 1754–61. https://doi.org/10.55563/clinexprheumatol/8snr4x.
Smith ID, Lu N, Wei J, Zhang Y, Choi HK, Bolster MB. Alcohol consumption and the risk of mortality and myocardial infarction in patients with rheumatoid arthritis. Clinical and experimental rheumatology. 2022 Sep;40(9):1754–61.
Smith, Isaac D., et al. “Alcohol consumption and the risk of mortality and myocardial infarction in patients with rheumatoid arthritis.Clinical and Experimental Rheumatology, vol. 40, no. 9, Sept. 2022, pp. 1754–61. Epmc, doi:10.55563/clinexprheumatol/8snr4x.
Smith ID, Lu N, Wei J, Zhang Y, Choi HK, Bolster MB. Alcohol consumption and the risk of mortality and myocardial infarction in patients with rheumatoid arthritis. Clinical and experimental rheumatology. 2022 Sep;40(9):1754–1761.

Published In

Clinical and experimental rheumatology

DOI

EISSN

1593-098X

ISSN

0392-856X

Publication Date

September 2022

Volume

40

Issue

9

Start / End Page

1754 / 1761

Related Subject Headings

  • Risk Factors
  • Myocardial Infarction
  • Methotrexate
  • Humans
  • Cohort Studies
  • Arthritis, Rheumatoid
  • Arthritis & Rheumatology
  • Alcohol Drinking
  • 3202 Clinical sciences
  • 1103 Clinical Sciences