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Vestibulotoxicity in a patient without renal failure after inhaled tobramycin.

Publication ,  Journal Article
Kaufman, AC; Eliades, SJ
Published in: Am J Otolaryngol
2019

Aminoglycoside antibiotics have a long history of use in the control of gram-negative bacterial infections, but their systemic use has been complicated by known ototoxicity and nephrotoxicity. Because of the utility of these medications in patients with frequent pulmonary infections, there has been a move towards the use of inhaled agents, in particular tobramycin, due to a lower rate of systemic complications. Inhaled tobramycin is generally consider to be safe from otologic complications, with only two previous reports of ototoxicity, both in patients who had underlying chronic renal disease. Here we present the first case of a patient developing isolated vestibular toxicity, without associated hearing loss or evidence of renal insufficiency, in a patient receiving inhaled tobramycin. This is an extremely rare complication of an inhaled aminoglycoside and underscores the importance of careful monitoring despite perceived safety.

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Published In

Am J Otolaryngol

DOI

EISSN

1532-818X

Publication Date

2019

Volume

40

Issue

3

Start / End Page

456 / 458

Location

United States

Related Subject Headings

  • Vestibular Function Tests
  • Vestibular Diseases
  • Treatment Outcome
  • Tobramycin
  • Renal Insufficiency
  • Pseudomonas aeruginosa
  • Pseudomonas Infections
  • Pneumonia, Bacterial
  • Otorhinolaryngology
  • Male
 

Citation

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Kaufman, A. C., & Eliades, S. J. (2019). Vestibulotoxicity in a patient without renal failure after inhaled tobramycin. Am J Otolaryngol, 40(3), 456–458. https://doi.org/10.1016/j.amjoto.2019.03.012
Kaufman, Adam C., and Steven J. Eliades. “Vestibulotoxicity in a patient without renal failure after inhaled tobramycin.Am J Otolaryngol 40, no. 3 (2019): 456–58. https://doi.org/10.1016/j.amjoto.2019.03.012.
Kaufman AC, Eliades SJ. Vestibulotoxicity in a patient without renal failure after inhaled tobramycin. Am J Otolaryngol. 2019;40(3):456–8.
Kaufman, Adam C., and Steven J. Eliades. “Vestibulotoxicity in a patient without renal failure after inhaled tobramycin.Am J Otolaryngol, vol. 40, no. 3, 2019, pp. 456–58. Pubmed, doi:10.1016/j.amjoto.2019.03.012.
Kaufman AC, Eliades SJ. Vestibulotoxicity in a patient without renal failure after inhaled tobramycin. Am J Otolaryngol. 2019;40(3):456–458.
Journal cover image

Published In

Am J Otolaryngol

DOI

EISSN

1532-818X

Publication Date

2019

Volume

40

Issue

3

Start / End Page

456 / 458

Location

United States

Related Subject Headings

  • Vestibular Function Tests
  • Vestibular Diseases
  • Treatment Outcome
  • Tobramycin
  • Renal Insufficiency
  • Pseudomonas aeruginosa
  • Pseudomonas Infections
  • Pneumonia, Bacterial
  • Otorhinolaryngology
  • Male