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Radiation therapy improves survival in patients with testicular diffuse large B-cell lymphoma.

Publication ,  Journal Article
Ho, JC; Dabaja, BS; Milgrom, SA; Smith, GL; Reddy, JP; Mazloom, A; Young, KH; Deng, L; Medeiros, LJ; Dong, W; Allen, PK; Andraos, TY; Oki, Y ...
Published in: Leuk Lymphoma
December 2017

In 120 Stage I-IV testicular diffuse large B-cell lymphoma (DLBCL) patients treated from 1964 to 2015, we assessed the benefits of prophylactic contralateral testicular radiation (RT) and prophylactic central nervous system (CNS) therapy on overall, progression free, testicular relapse free, and CNS relapse free survival (OS, PFS, TRFS, and CRFS, respectively). Seventy percent of patients received RT, 53% received anthracyclines and rituximab (modern therapy), and 61% received CNS prophylaxis. On univariate analysis RT was associated with improved TRFS, PFS, and trended toward improved OS. On multivariate analysis (MVA), RT was significantly associated with improved OS and PFS; the PFS benefit persisted among patients receiving modern therapy. CNS prophylaxis was associated with improved OS, PFS, and TRFS, but not CRFS on univariate analysis, and was not significant on MVA. RT is associated with improved survival, and should be considered for all testicular DLBCL patients, but additional strategies are needed to prevent CNS relapse.

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Published In

Leuk Lymphoma

DOI

EISSN

1029-2403

Publication Date

December 2017

Volume

58

Issue

12

Start / End Page

2833 / 2844

Location

United States

Related Subject Headings

  • Young Adult
  • Testicular Neoplasms
  • Radiotherapy
  • Neoplasm Staging
  • Multimodal Imaging
  • Middle Aged
  • Male
  • Lymphoma, Large B-Cell, Diffuse
  • Immunology
  • Humans
 

Citation

APA
Chicago
ICMJE
MLA
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Ho, J. C., Dabaja, B. S., Milgrom, S. A., Smith, G. L., Reddy, J. P., Mazloom, A., … Pinnix, C. C. (2017). Radiation therapy improves survival in patients with testicular diffuse large B-cell lymphoma. Leuk Lymphoma, 58(12), 2833–2844. https://doi.org/10.1080/10428194.2017.1312381
Ho, Jennifer C., Bouthaina S. Dabaja, Sarah A. Milgrom, Grace L. Smith, Jay P. Reddy, Ali Mazloom, Ken H. Young, et al. “Radiation therapy improves survival in patients with testicular diffuse large B-cell lymphoma.Leuk Lymphoma 58, no. 12 (December 2017): 2833–44. https://doi.org/10.1080/10428194.2017.1312381.
Ho JC, Dabaja BS, Milgrom SA, Smith GL, Reddy JP, Mazloom A, et al. Radiation therapy improves survival in patients with testicular diffuse large B-cell lymphoma. Leuk Lymphoma. 2017 Dec;58(12):2833–44.
Ho, Jennifer C., et al. “Radiation therapy improves survival in patients with testicular diffuse large B-cell lymphoma.Leuk Lymphoma, vol. 58, no. 12, Dec. 2017, pp. 2833–44. Pubmed, doi:10.1080/10428194.2017.1312381.
Ho JC, Dabaja BS, Milgrom SA, Smith GL, Reddy JP, Mazloom A, Young KH, Deng L, Medeiros LJ, Dong W, Allen PK, Andraos TY, Fowler NH, Nastoupil LJ, Oki Y, Fayad LE, Turturro F, Neelapu SS, Westin J, Hagemeister FB, Rodriguez MA, Pinnix CC. Radiation therapy improves survival in patients with testicular diffuse large B-cell lymphoma. Leuk Lymphoma. 2017 Dec;58(12):2833–2844.

Published In

Leuk Lymphoma

DOI

EISSN

1029-2403

Publication Date

December 2017

Volume

58

Issue

12

Start / End Page

2833 / 2844

Location

United States

Related Subject Headings

  • Young Adult
  • Testicular Neoplasms
  • Radiotherapy
  • Neoplasm Staging
  • Multimodal Imaging
  • Middle Aged
  • Male
  • Lymphoma, Large B-Cell, Diffuse
  • Immunology
  • Humans