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Myeloblast phenotypic changes in myelodysplasia. CD34 and CD117 expression abnormalities are common.

Publication ,  Journal Article
Pirruccello, SJ; Young, KH; Aoun, P
Published in: Am J Clin Pathol
June 2006

We used a new method of data presentation and analysis, termed antigen mapping, to characterize recurring myeloblast phenotypic abnormalities in a series of 28 cases of myelodysplastic syndrome (MDS), including refractory anemia with ringed sideroblasts (RARS), refractory anemia with multilineage dysplasia (RCMLD), and refractory anemia with excess blasts (RAEB). Abnormal patterns of CD34 and CD117 expression were present in 50% of RARS, 68% of RCMLD, and 100% of RAEB cases. The presence of decreased myeloblast CD45 density, increased CD13 and CD34 density, and increased expression of CD11c and CD4(dim) were MDS grade-related. There was a direct relationship between the number of myeloblast phenotypic abnormalities (phenotypic score) and MDS grade. The myeloblast phenotypic scores also were correlated highly with International Prognostic Scoring System scores and risk categories. We found the antigen mapping technique to be an efficient data presentation and analysis method for the detection of MDS-associated abnormalities of antigen distribution and density.

Duke Scholars

Published In

Am J Clin Pathol

DOI

ISSN

0002-9173

Publication Date

June 2006

Volume

125

Issue

6

Start / End Page

884 / 894

Location

England

Related Subject Headings

  • Proto-Oncogene Proteins c-kit
  • Phenotype
  • Pathology
  • Middle Aged
  • Male
  • Immunophenotyping
  • Humans
  • Granulocyte Precursor Cells
  • Female
  • Epitope Mapping
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Pirruccello, S. J., Young, K. H., & Aoun, P. (2006). Myeloblast phenotypic changes in myelodysplasia. CD34 and CD117 expression abnormalities are common. Am J Clin Pathol, 125(6), 884–894. https://doi.org/10.1309/j3et7rxd1x4bkdlf
Pirruccello, Samuel J., Ken H. Young, and Patricia Aoun. “Myeloblast phenotypic changes in myelodysplasia. CD34 and CD117 expression abnormalities are common.Am J Clin Pathol 125, no. 6 (June 2006): 884–94. https://doi.org/10.1309/j3et7rxd1x4bkdlf.
Pirruccello SJ, Young KH, Aoun P. Myeloblast phenotypic changes in myelodysplasia. CD34 and CD117 expression abnormalities are common. Am J Clin Pathol. 2006 Jun;125(6):884–94.
Pirruccello, Samuel J., et al. “Myeloblast phenotypic changes in myelodysplasia. CD34 and CD117 expression abnormalities are common.Am J Clin Pathol, vol. 125, no. 6, June 2006, pp. 884–94. Pubmed, doi:10.1309/j3et7rxd1x4bkdlf.
Pirruccello SJ, Young KH, Aoun P. Myeloblast phenotypic changes in myelodysplasia. CD34 and CD117 expression abnormalities are common. Am J Clin Pathol. 2006 Jun;125(6):884–894.
Journal cover image

Published In

Am J Clin Pathol

DOI

ISSN

0002-9173

Publication Date

June 2006

Volume

125

Issue

6

Start / End Page

884 / 894

Location

England

Related Subject Headings

  • Proto-Oncogene Proteins c-kit
  • Phenotype
  • Pathology
  • Middle Aged
  • Male
  • Immunophenotyping
  • Humans
  • Granulocyte Precursor Cells
  • Female
  • Epitope Mapping