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Self-Reported Health Outcomes of Children and Youth with 10 Chronic Diseases.

Publication ,  Journal Article
Forrest, CB; Schuchard, J; Bruno, C; Amaral, S; Cox, ED; Flynn, KE; Hinds, PS; Huang, I-C; Kappelman, MD; Krishnan, JA; Kumar, RB; Lai, J-S ...
Published in: J Pediatr
July 2022

OBJECTIVES: To identify pediatric patient-reported outcomes (PROs) that are associated with chronic conditions and to evaluate the effects of chronic disease activity on PROs. STUDY DESIGN: Participants (8-24 years old) and their parents were enrolled into 14 studies that evaluated Patient-Reported Outcome Measurement Information System PROs across 10 chronic conditions-asthma, atopic dermatitis, cancer, cancer survivors, chronic kidney disease, Crohn's disease, juvenile idiopathic arthritis, lupus, sickle cell disease, and type 1 diabetes mellitus. PRO scores were contrasted with the US general population of children using nationally representative percentiles. PRO-specific coefficients of variation were computed to illustrate the degree of variation in scores within vs between conditions. Condition-specific measures of disease severity and Cohen d effect sizes were used to examine PRO scores by disease activity. RESULTS: Participants included 2975 child respondents and 2392 parent respondents who provided data for 3409 unique children: 52% were 5-12 years old, 52% female, 25% African American/Black, and 14% Hispanic. Across all 10 chronic conditions, children reported more anxiety, fatigue, pain, and mobility restrictions than the general pediatric population. Variation in PRO scores within chronic disease cohorts was equivalent to variation within the general population, exceeding between-cohort variation by factors of 1.9 (mobility) to 5.7 (anxiety). Disease activity was consistently associated with poorer self-reported health, and these effects were weakest for peer relationships. CONCLUSIONS: Chronic conditions are associated with symptoms and functional status in children and adolescents across 10 different disorders. These findings highlight the need to complement conventional clinical evaluations with those obtained directly from patients themselves using PROs.

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Published In

J Pediatr

DOI

EISSN

1097-6833

Publication Date

July 2022

Volume

246

Start / End Page

207 / 212.e1

Location

United States

Related Subject Headings

  • Young Adult
  • Self Report
  • Quality of Life
  • Pediatrics
  • Patient Reported Outcome Measures
  • Male
  • Humans
  • Female
  • Fatigue
  • Chronic Disease
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Forrest, C. B., Schuchard, J., Bruno, C., Amaral, S., Cox, E. D., Flynn, K. E., … Reeve, B. B. (2022). Self-Reported Health Outcomes of Children and Youth with 10 Chronic Diseases. J Pediatr, 246, 207-212.e1. https://doi.org/10.1016/j.jpeds.2022.02.052
Forrest, Christopher B., Julia Schuchard, Cortney Bruno, Sandra Amaral, Elizabeth D. Cox, Kathryn E. Flynn, Pamela S. Hinds, et al. “Self-Reported Health Outcomes of Children and Youth with 10 Chronic Diseases.J Pediatr 246 (July 2022): 207-212.e1. https://doi.org/10.1016/j.jpeds.2022.02.052.
Forrest CB, Schuchard J, Bruno C, Amaral S, Cox ED, Flynn KE, et al. Self-Reported Health Outcomes of Children and Youth with 10 Chronic Diseases. J Pediatr. 2022 Jul;246:207-212.e1.
Forrest, Christopher B., et al. “Self-Reported Health Outcomes of Children and Youth with 10 Chronic Diseases.J Pediatr, vol. 246, July 2022, pp. 207-212.e1. Pubmed, doi:10.1016/j.jpeds.2022.02.052.
Forrest CB, Schuchard J, Bruno C, Amaral S, Cox ED, Flynn KE, Hinds PS, Huang I-C, Kappelman MD, Krishnan JA, Kumar RB, Lai J-S, Paller AS, Phipatanakul W, Schanberg LE, Sumino K, Weitzman ER, Reeve BB. Self-Reported Health Outcomes of Children and Youth with 10 Chronic Diseases. J Pediatr. 2022 Jul;246:207-212.e1.
Journal cover image

Published In

J Pediatr

DOI

EISSN

1097-6833

Publication Date

July 2022

Volume

246

Start / End Page

207 / 212.e1

Location

United States

Related Subject Headings

  • Young Adult
  • Self Report
  • Quality of Life
  • Pediatrics
  • Patient Reported Outcome Measures
  • Male
  • Humans
  • Female
  • Fatigue
  • Chronic Disease