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An Update on Innate Immune Responses during SARS-CoV-2 Infection.

Publication ,  Journal Article
Zhang, Y; Chen, S; Jin, Y; Ji, W; Zhang, W; Duan, G
Published in: Viruses
October 2021

The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a member of the Coronaviridae family, which is responsible for the COVID-19 pandemic followed by unprecedented global societal and economic disruptive impact. The innate immune system is the body's first line of defense against invading pathogens and is induced by a variety of cellular receptors that sense viral components. However, various strategies are exploited by SARS-CoV-2 to disrupt the antiviral innate immune responses. Innate immune dysfunction is characterized by the weak generation of type I interferons (IFNs) and the hypersecretion of pro-inflammatory cytokines, leading to mortality and organ injury in patients with COVID-19. This review summarizes the existing understanding of the mutual effects between SARS-CoV-2 and the type I IFN (IFN-α/β) responses, emphasizing the relationship between host innate immune signaling and viral proteases with an insight on tackling potential therapeutic targets.

Duke Scholars

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Published In

Viruses

DOI

EISSN

1999-4915

ISSN

1999-4915

Publication Date

October 2021

Volume

13

Issue

10

Start / End Page

2060

Related Subject Headings

  • Signal Transduction
  • SARS-CoV-2
  • Ritonavir
  • Ribavirin
  • Lopinavir
  • Interferon Type I
  • Immunity, Innate
  • Immune Evasion
  • Humans
  • Drug Combinations
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Zhang, Y., Chen, S., Jin, Y., Ji, W., Zhang, W., & Duan, G. (2021). An Update on Innate Immune Responses during SARS-CoV-2 Infection. Viruses, 13(10), 2060. https://doi.org/10.3390/v13102060
Zhang, Yu, Shuaiyin Chen, Yuefei Jin, Wangquan Ji, Weiguo Zhang, and Guangcai Duan. “An Update on Innate Immune Responses during SARS-CoV-2 Infection.Viruses 13, no. 10 (October 2021): 2060. https://doi.org/10.3390/v13102060.
Zhang Y, Chen S, Jin Y, Ji W, Zhang W, Duan G. An Update on Innate Immune Responses during SARS-CoV-2 Infection. Viruses. 2021 Oct;13(10):2060.
Zhang, Yu, et al. “An Update on Innate Immune Responses during SARS-CoV-2 Infection.Viruses, vol. 13, no. 10, Oct. 2021, p. 2060. Epmc, doi:10.3390/v13102060.
Zhang Y, Chen S, Jin Y, Ji W, Zhang W, Duan G. An Update on Innate Immune Responses during SARS-CoV-2 Infection. Viruses. 2021 Oct;13(10):2060.

Published In

Viruses

DOI

EISSN

1999-4915

ISSN

1999-4915

Publication Date

October 2021

Volume

13

Issue

10

Start / End Page

2060

Related Subject Headings

  • Signal Transduction
  • SARS-CoV-2
  • Ritonavir
  • Ribavirin
  • Lopinavir
  • Interferon Type I
  • Immunity, Innate
  • Immune Evasion
  • Humans
  • Drug Combinations