An Update on Innate Immune Responses during SARS-CoV-2 Infection.
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a member of the Coronaviridae family, which is responsible for the COVID-19 pandemic followed by unprecedented global societal and economic disruptive impact. The innate immune system is the body's first line of defense against invading pathogens and is induced by a variety of cellular receptors that sense viral components. However, various strategies are exploited by SARS-CoV-2 to disrupt the antiviral innate immune responses. Innate immune dysfunction is characterized by the weak generation of type I interferons (IFNs) and the hypersecretion of pro-inflammatory cytokines, leading to mortality and organ injury in patients with COVID-19. This review summarizes the existing understanding of the mutual effects between SARS-CoV-2 and the type I IFN (IFN-α/β) responses, emphasizing the relationship between host innate immune signaling and viral proteases with an insight on tackling potential therapeutic targets.
Duke Scholars
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Related Subject Headings
- Signal Transduction
- SARS-CoV-2
- Ritonavir
- Ribavirin
- Lopinavir
- Interferon Type I
- Immunity, Innate
- Immune Evasion
- Humans
- Drug Combinations
Citation
Published In
DOI
EISSN
ISSN
Publication Date
Volume
Issue
Start / End Page
Related Subject Headings
- Signal Transduction
- SARS-CoV-2
- Ritonavir
- Ribavirin
- Lopinavir
- Interferon Type I
- Immunity, Innate
- Immune Evasion
- Humans
- Drug Combinations