Skip to main content

An Update on Innate Immune Responses during SARS-CoV-2 Infection.

Publication ,  Journal Article
Zhang, Y; Chen, S; Jin, Y; Ji, W; Zhang, W; Duan, G
Published in: Viruses
October 14, 2021

The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a member of the Coronaviridae family, which is responsible for the COVID-19 pandemic followed by unprecedented global societal and economic disruptive impact. The innate immune system is the body's first line of defense against invading pathogens and is induced by a variety of cellular receptors that sense viral components. However, various strategies are exploited by SARS-CoV-2 to disrupt the antiviral innate immune responses. Innate immune dysfunction is characterized by the weak generation of type I interferons (IFNs) and the hypersecretion of pro-inflammatory cytokines, leading to mortality and organ injury in patients with COVID-19. This review summarizes the existing understanding of the mutual effects between SARS-CoV-2 and the type I IFN (IFN-α/β) responses, emphasizing the relationship between host innate immune signaling and viral proteases with an insight on tackling potential therapeutic targets.

Duke Scholars

Altmetric Attention Stats
Dimensions Citation Stats

Published In

Viruses

DOI

EISSN

1999-4915

Publication Date

October 14, 2021

Volume

13

Issue

10

Location

Switzerland

Related Subject Headings

  • Signal Transduction
  • SARS-CoV-2
  • Ritonavir
  • Ribavirin
  • Lopinavir
  • Interferon Type I
  • Immunity, Innate
  • Immune Evasion
  • Humans
  • Drug Combinations
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Zhang, Y., Chen, S., Jin, Y., Ji, W., Zhang, W., & Duan, G. (2021). An Update on Innate Immune Responses during SARS-CoV-2 Infection. Viruses, 13(10). https://doi.org/10.3390/v13102060
Zhang, Yu, Shuaiyin Chen, Yuefei Jin, Wangquan Ji, Weiguo Zhang, and Guangcai Duan. “An Update on Innate Immune Responses during SARS-CoV-2 Infection.Viruses 13, no. 10 (October 14, 2021). https://doi.org/10.3390/v13102060.
Zhang Y, Chen S, Jin Y, Ji W, Zhang W, Duan G. An Update on Innate Immune Responses during SARS-CoV-2 Infection. Viruses. 2021 Oct 14;13(10).
Zhang, Yu, et al. “An Update on Innate Immune Responses during SARS-CoV-2 Infection.Viruses, vol. 13, no. 10, Oct. 2021. Pubmed, doi:10.3390/v13102060.
Zhang Y, Chen S, Jin Y, Ji W, Zhang W, Duan G. An Update on Innate Immune Responses during SARS-CoV-2 Infection. Viruses. 2021 Oct 14;13(10).

Published In

Viruses

DOI

EISSN

1999-4915

Publication Date

October 14, 2021

Volume

13

Issue

10

Location

Switzerland

Related Subject Headings

  • Signal Transduction
  • SARS-CoV-2
  • Ritonavir
  • Ribavirin
  • Lopinavir
  • Interferon Type I
  • Immunity, Innate
  • Immune Evasion
  • Humans
  • Drug Combinations