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Impact of perinatal management on neurodevelopmental outcomes in congenital heart disease.

Publication ,  Journal Article
Sethi, N; Carpenter, JL; Donofrio, MT
Published in: Semin Perinatol
June 2022

With advancements in cardiopulmonary bypass technique and perioperative care, there has been a progressive decline in mortality associated with neonatal surgical correction of congenital heart disease (CHD). Thus, there is now increased focus on improving neurodevelopmental outcomes in CHD survivors. While the cause of these neurodevelopmental impairments is multifactorial, there is increasing evidence that structural and functional cerebral abnormalities are present before cardiac corrective repair. This suggests that in addition to patient specific risk factors, underlying cardiac physiology and clinical hemodynamics are critical to brain health and development. Prenatal diagnosis of CHD and subsequent optimization of perinatal care may therefore be important modifiable factors for long-term neurodevelopmental outcome. This article reviews the impact that prenatal diagnosis of CHD has on perinatal care and the preoperative clinical status of a neonate, as well as the potential influence this may have on lessening the degree of cerebral injury and long-term neurodevelopmental impairments.

Duke Scholars

Published In

Semin Perinatol

DOI

EISSN

1558-075X

Publication Date

June 2022

Volume

46

Issue

4

Start / End Page

151582

Location

United States

Related Subject Headings

  • Prenatal Diagnosis
  • Pregnancy
  • Obstetrics & Reproductive Medicine
  • Infant, Newborn
  • Humans
  • Heart Defects, Congenital
  • Female
  • Cardiac Surgical Procedures
  • Brain Injuries
  • Brain
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Sethi, N., Carpenter, J. L., & Donofrio, M. T. (2022). Impact of perinatal management on neurodevelopmental outcomes in congenital heart disease. Semin Perinatol, 46(4), 151582. https://doi.org/10.1016/j.semperi.2022.151582
Journal cover image

Published In

Semin Perinatol

DOI

EISSN

1558-075X

Publication Date

June 2022

Volume

46

Issue

4

Start / End Page

151582

Location

United States

Related Subject Headings

  • Prenatal Diagnosis
  • Pregnancy
  • Obstetrics & Reproductive Medicine
  • Infant, Newborn
  • Humans
  • Heart Defects, Congenital
  • Female
  • Cardiac Surgical Procedures
  • Brain Injuries
  • Brain