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Decline in attention-deficit hyperactivity disorder traits over the life course in the general population: trajectories across five population birth cohorts spanning ages 3 to 45 years.

Publication ,  Journal Article
Wootton, RE; Riglin, L; Blakey, R; Agnew-Blais, J; Caye, A; Cadman, T; Havdahl, A; Gonçalves, H; Menezes, AMB; Wehrmeister, FC; Rimfeld, K ...
Published in: International journal of epidemiology
June 2022

Trajectories of attention-deficit hyperactivity disorder (ADHD) traits spanning early childhood to mid-life have not been described in general populations across different geographical contexts. Population trajectories are crucial to better understanding typical developmental patterns.We combined repeated assessments of ADHD traits from five population-based cohorts, spanning ages 3 to 45 years. We used two measures: (i) the Strengths and Difficulties Questionnaire (SDQ) hyperactive-inattentive subscale (175 831 observations, 29 519 individuals); and (ii) scores from DSM-referenced scales (118 144 observations, 28 685 individuals). Multilevel linear spline models allowed for non-linear change over time and differences between cohorts and raters (parent/teacher/self).Patterns of age-related change differed by measure, cohort and country: overall, SDQ scores decreased with age, most rapidly declining before age 8 years (-0.157, 95% CI: -0.170, -0.144 per year). The pattern was generally consistent using DSM scores, although with greater between-cohort variation. DSM scores decreased most rapidly between ages 14 and 17 years (-1.32%, 95% CI: -1.471, -1.170 per year). Average scores were consistently lower for females than males (SDQ: -0.818, 95% CI: -0.856, -0.780; DSM: -4.934%, 95% CI: -5.378, -4.489). This sex difference decreased over age for both measures, due to an overall steeper decrease for males.ADHD trait scores declined from childhood to mid-life, with marked variation between cohorts. Our results highlight the importance of taking a developmental perspective when considering typical population traits. When interpreting changes in clinical cohorts, it is important to consider the pattern of expected change within the general population, which is influenced by cultural context and measurement.

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Published In

International journal of epidemiology

DOI

EISSN

1464-3685

ISSN

0300-5771

Publication Date

June 2022

Volume

51

Issue

3

Start / End Page

919 / 930

Related Subject Headings

  • Young Adult
  • Phenotype
  • Middle Aged
  • Male
  • Life Change Events
  • Humans
  • Female
  • Epidemiology
  • Cohort Studies
  • Child, Preschool
 

Citation

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Chicago
ICMJE
MLA
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Wootton, R. E., Riglin, L., Blakey, R., Agnew-Blais, J., Caye, A., Cadman, T., … Tilling, K. (2022). Decline in attention-deficit hyperactivity disorder traits over the life course in the general population: trajectories across five population birth cohorts spanning ages 3 to 45 years. International Journal of Epidemiology, 51(3), 919–930. https://doi.org/10.1093/ije/dyac049
Wootton, Robyn E., Lucy Riglin, Rachel Blakey, Jessica Agnew-Blais, Arthur Caye, Tim Cadman, Alexandra Havdahl, et al. “Decline in attention-deficit hyperactivity disorder traits over the life course in the general population: trajectories across five population birth cohorts spanning ages 3 to 45 years.International Journal of Epidemiology 51, no. 3 (June 2022): 919–30. https://doi.org/10.1093/ije/dyac049.
Wootton RE, Riglin L, Blakey R, Agnew-Blais J, Caye A, Cadman T, et al. Decline in attention-deficit hyperactivity disorder traits over the life course in the general population: trajectories across five population birth cohorts spanning ages 3 to 45 years. International journal of epidemiology. 2022 Jun;51(3):919–30.
Wootton, Robyn E., et al. “Decline in attention-deficit hyperactivity disorder traits over the life course in the general population: trajectories across five population birth cohorts spanning ages 3 to 45 years.International Journal of Epidemiology, vol. 51, no. 3, June 2022, pp. 919–30. Epmc, doi:10.1093/ije/dyac049.
Wootton RE, Riglin L, Blakey R, Agnew-Blais J, Caye A, Cadman T, Havdahl A, Gonçalves H, Menezes AMB, Wehrmeister FC, Rimfeld K, Davey Smith G, Eley TC, Rohde LA, Arseneault L, Moffitt TE, Stergiakouli E, Thapar A, Tilling K. Decline in attention-deficit hyperactivity disorder traits over the life course in the general population: trajectories across five population birth cohorts spanning ages 3 to 45 years. International journal of epidemiology. 2022 Jun;51(3):919–930.
Journal cover image

Published In

International journal of epidemiology

DOI

EISSN

1464-3685

ISSN

0300-5771

Publication Date

June 2022

Volume

51

Issue

3

Start / End Page

919 / 930

Related Subject Headings

  • Young Adult
  • Phenotype
  • Middle Aged
  • Male
  • Life Change Events
  • Humans
  • Female
  • Epidemiology
  • Cohort Studies
  • Child, Preschool