Skip to main content
Journal cover image

Economic and clinical burden associated with respiratory viral infections after allogeneic hematopoietic cell transplant in the United States.

Publication ,  Journal Article
Ison, MG; Marty, FM; Chao, N; Moon, SH; Zhang, Z; Chandak, A
Published in: Transpl Infect Dis
August 2022

BACKGROUND: Allogeneic hematopoietic cell transplant (allo-HCT) recipients are at increased risk for respiratory viral infections (RVIs), which invoke substantial morbidity and mortality. Limited effective antiviral options and drug resistance often hamper successful RVI treatment, creating additional burden for patients and the health care system. METHODS: Using an open-source health care claims database, we examined differences in clinical outcomes, health resource utilization, and total reimbursements during the 1-year period following allo-HCT in patients with and without any RVI infection (respiratory syncytial virus, influenza, parainfluenza virus, and human metapneumovirus). RVIs were diagnosed at any time ≤1 year after allo-HCT and identified by International Classification of Disease codes. Analyses were stratified by the presence or absence of acute or chronic graft-versus-host disease (GVHD). RESULTS: The study included 13 363 allo-HCT patients, 1368 (10.2%) of whom had a diagnostic code for any RVI. A higher proportion of patients with any RVI had pneumonia ≤1 year after allo-HCT compared to patients without any RVI, with or without GVHD. Patients with any RVI had higher all-cause mortality risk, longer length of post-allo-HCT hospital stay, higher readmission rate, and higher number of hospital days after allo-HCT compared to patients without the infection (all p < .05). Total unadjusted median reimbursements were higher for those with any RVI and each specific RVI assessed than those without the specific infection, with or without GVHD. CONCLUSION: Allo-HCT patients with RVIs had significantly worse clinical outcomes and increased health resource utilization and reimbursements during the year following allo-HCT, with or without GVHD.

Duke Scholars

Altmetric Attention Stats
Dimensions Citation Stats

Published In

Transpl Infect Dis

DOI

EISSN

1399-3062

Publication Date

August 2022

Volume

24

Issue

4

Start / End Page

e13866

Location

Denmark

Related Subject Headings

  • Virus Diseases
  • United States
  • Surgery
  • Retrospective Studies
  • Respiratory Tract Infections
  • Respiratory Syncytial Viruses
  • Humans
  • Hematopoietic Stem Cell Transplantation
  • Graft vs Host Disease
  • 3202 Clinical sciences
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Ison, M. G., Marty, F. M., Chao, N., Moon, S. H., Zhang, Z., & Chandak, A. (2022). Economic and clinical burden associated with respiratory viral infections after allogeneic hematopoietic cell transplant in the United States. Transpl Infect Dis, 24(4), e13866. https://doi.org/10.1111/tid.13866
Ison, Michael G., Francisco M. Marty, Nelson Chao, Seung Hyun Moon, Zhiji Zhang, and Aastha Chandak. “Economic and clinical burden associated with respiratory viral infections after allogeneic hematopoietic cell transplant in the United States.Transpl Infect Dis 24, no. 4 (August 2022): e13866. https://doi.org/10.1111/tid.13866.
Ison MG, Marty FM, Chao N, Moon SH, Zhang Z, Chandak A. Economic and clinical burden associated with respiratory viral infections after allogeneic hematopoietic cell transplant in the United States. Transpl Infect Dis. 2022 Aug;24(4):e13866.
Ison, Michael G., et al. “Economic and clinical burden associated with respiratory viral infections after allogeneic hematopoietic cell transplant in the United States.Transpl Infect Dis, vol. 24, no. 4, Aug. 2022, p. e13866. Pubmed, doi:10.1111/tid.13866.
Ison MG, Marty FM, Chao N, Moon SH, Zhang Z, Chandak A. Economic and clinical burden associated with respiratory viral infections after allogeneic hematopoietic cell transplant in the United States. Transpl Infect Dis. 2022 Aug;24(4):e13866.
Journal cover image

Published In

Transpl Infect Dis

DOI

EISSN

1399-3062

Publication Date

August 2022

Volume

24

Issue

4

Start / End Page

e13866

Location

Denmark

Related Subject Headings

  • Virus Diseases
  • United States
  • Surgery
  • Retrospective Studies
  • Respiratory Tract Infections
  • Respiratory Syncytial Viruses
  • Humans
  • Hematopoietic Stem Cell Transplantation
  • Graft vs Host Disease
  • 3202 Clinical sciences