Skip to main content
release_alert
Welcome to the new Scholars 3.0! Read about new features and let us know what you think.
cancel
Journal cover image

Histologic grading correlates with inflammatory biomarkers in tibialis posterior tendon dysfunction.

Publication ,  Journal Article
Danilkowicz, RM; Parekh, SG; Tainter, DM; Allen, N; O'Donnell, J; Hanselman, A; Adams, SB
Published in: Foot Ankle Surg
December 2022

BACKGROUND: It has been theorized that tibialis posterior tendon dysfunction (TPTD) is a degenerative process unrelated to inflammation. The purpose of this study was to determine if inflammatory cytokines, matrix metalloproteases (MMPs), and glutamate were elevated in diseased tibialis posterior tendons (TPTs). METHODS: Matched diseased TPT, TPT insertion, and flexor digitorum longus (FDL) samples were collected from 21 patients. The samples were individually incubated in media, which was analyzed for inflammatory cytokines, MMPs, and glutamate. Histology and statistical analyses were performed. RESULTS: Diseased TPT and TPT insertion were significantly elevated compared to transferred FDL in eight inflammatory markers (p < 0.005). Only the diseased TPT was significantly elevated compared to the transferred FDL tendons for glutamate (p < 0.01). Histologic grading correlated with inflammatory cytokine levels. CONCLUSION: Diseased TPT and TPT insertion demonstrated significantly elevated levels of inflammatory markers compared to the transferred tendons used as controls, suggesting a role for inflammation in the disease process. The amount of inflammation correlated with increased tendon degradation. LEVEL OF EVIDENCE: Level III.

Duke Scholars

Published In

Foot Ankle Surg

DOI

EISSN

1460-9584

Publication Date

December 2022

Volume

28

Issue

8

Start / End Page

1266 / 1271

Location

France

Related Subject Headings

  • Tendons
  • Tendon Transfer
  • Posterior Tibial Tendon Dysfunction
  • Orthopedics
  • Humans
  • Glutamic Acid
  • Foot
  • 1103 Clinical Sciences
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Danilkowicz, R. M., Parekh, S. G., Tainter, D. M., Allen, N., O’Donnell, J., Hanselman, A., & Adams, S. B. (2022). Histologic grading correlates with inflammatory biomarkers in tibialis posterior tendon dysfunction. Foot Ankle Surg, 28(8), 1266–1271. https://doi.org/10.1016/j.fas.2022.05.004
Danilkowicz, Richard M., Selene G. Parekh, David M. Tainter, Nicholas Allen, Jeffrey O’Donnell, Andrew Hanselman, and Samuel B. Adams. “Histologic grading correlates with inflammatory biomarkers in tibialis posterior tendon dysfunction.Foot Ankle Surg 28, no. 8 (December 2022): 1266–71. https://doi.org/10.1016/j.fas.2022.05.004.
Danilkowicz RM, Parekh SG, Tainter DM, Allen N, O’Donnell J, Hanselman A, et al. Histologic grading correlates with inflammatory biomarkers in tibialis posterior tendon dysfunction. Foot Ankle Surg. 2022 Dec;28(8):1266–71.
Danilkowicz, Richard M., et al. “Histologic grading correlates with inflammatory biomarkers in tibialis posterior tendon dysfunction.Foot Ankle Surg, vol. 28, no. 8, Dec. 2022, pp. 1266–71. Pubmed, doi:10.1016/j.fas.2022.05.004.
Danilkowicz RM, Parekh SG, Tainter DM, Allen N, O’Donnell J, Hanselman A, Adams SB. Histologic grading correlates with inflammatory biomarkers in tibialis posterior tendon dysfunction. Foot Ankle Surg. 2022 Dec;28(8):1266–1271.
Journal cover image

Published In

Foot Ankle Surg

DOI

EISSN

1460-9584

Publication Date

December 2022

Volume

28

Issue

8

Start / End Page

1266 / 1271

Location

France

Related Subject Headings

  • Tendons
  • Tendon Transfer
  • Posterior Tibial Tendon Dysfunction
  • Orthopedics
  • Humans
  • Glutamic Acid
  • Foot
  • 1103 Clinical Sciences