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Profiling hepatocellular carcinoma aggressiveness with contrast-enhanced ultrasound and gadoxetate disodium-enhanced MRI: An intra-individual comparative study based on the Liver Imaging Reporting and Data System.

Publication ,  Journal Article
Yang, J; Jiang, H; Xie, K; Bashir, MR; Wan, H; Huang, J; Qin, Y; Chen, J; Lu, Q; Song, B
Published in: Eur J Radiol
September 2022

PURPOSE: Contrast-enhanced ultrasound (CEUS) and gadoxetate disodium-enhanced MRI (EOB-MRI) may synergize in profiling hepatocellular carcinoma (HCC) aggressiveness considering distinct imaging traits. This study aimed to intra-individually compare CEUS and EOB-MRI with Liver Imaging Reporting and Data System (LI-RADS) in assessing HCC aggressiveness. METHOD: From January 2015 to November 2020, consecutive at-risk patients with surgically-confirmed HCC who underwent both preoperative CEUS and EOB-MRI examinations were retrospectively enrolled. Image analyses were conducted independently by two masked radiologists for CEUS and EOB-MRI, respectively. The diagnostic performance of each modality for macrovascular invasion against pathology was evaluated and compared with the McNemar's test, while Edmondson-Steiner grade and the presence of microvascular invasion (MVI) were compared between patients with and without LR-M features on each modality. RESULTS: A total of 140 patients (mean age, 51.9 years ± 11.0; 116 men) were included. Inter-modality agreement was poor (κ = -0.087 ∼ 0.139) for major LI-RADS features and moderate (κ = 0.449) for overall LI-RADS categorization, and LR-TIV and LR-M were the top sources of inter-modality variations. Although CEUS demonstrated significantly higher specificity for diagnosing macrovascular invasion (96% vs. 89%, P =.02), LR-M features on EOB-MRI were more effective in identifying higher Edmondson-Steiner grades (P =.01) and MVI (P =.02). CONCLUSIONS: Marked discrepancies were found between CEUS and EOB-MRI in evaluating LI-RADS features and categories. Whereas CEUS showed superior diagnostic specificity for macrovascular invasion, LR-M features on EOB-MRI provided more information regarding tumor grade and MVI status in HCC patients.

Duke Scholars

Published In

Eur J Radiol

DOI

EISSN

1872-7727

Publication Date

September 2022

Volume

154

Start / End Page

110397

Location

Ireland

Related Subject Headings

  • Sensitivity and Specificity
  • Retrospective Studies
  • Reproducibility of Results
  • Nuclear Medicine & Medical Imaging
  • Middle Aged
  • Male
  • Magnetic Resonance Imaging
  • Liver Neoplasms
  • Humans
  • Gadolinium DTPA
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Yang, J., Jiang, H., Xie, K., Bashir, M. R., Wan, H., Huang, J., … Song, B. (2022). Profiling hepatocellular carcinoma aggressiveness with contrast-enhanced ultrasound and gadoxetate disodium-enhanced MRI: An intra-individual comparative study based on the Liver Imaging Reporting and Data System. Eur J Radiol, 154, 110397. https://doi.org/10.1016/j.ejrad.2022.110397
Yang, Jie, Hanyu Jiang, Kunlin Xie, Mustafa R. Bashir, Haifeng Wan, Jiayan Huang, Yun Qin, Jie Chen, Qiang Lu, and Bin Song. “Profiling hepatocellular carcinoma aggressiveness with contrast-enhanced ultrasound and gadoxetate disodium-enhanced MRI: An intra-individual comparative study based on the Liver Imaging Reporting and Data System.Eur J Radiol 154 (September 2022): 110397. https://doi.org/10.1016/j.ejrad.2022.110397.
Journal cover image

Published In

Eur J Radiol

DOI

EISSN

1872-7727

Publication Date

September 2022

Volume

154

Start / End Page

110397

Location

Ireland

Related Subject Headings

  • Sensitivity and Specificity
  • Retrospective Studies
  • Reproducibility of Results
  • Nuclear Medicine & Medical Imaging
  • Middle Aged
  • Male
  • Magnetic Resonance Imaging
  • Liver Neoplasms
  • Humans
  • Gadolinium DTPA