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Using zebrafish to understand reciprocal interactions between the nervous and immune systems and the microbial world.

Publication ,  Journal Article
Levraud, J-P; Rawls, JF; Clatworthy, AE
Published in: J Neuroinflammation
June 28, 2022

Animals rely heavily on their nervous and immune systems to perceive and survive within their environment. Despite the traditional view of the brain as an immunologically privileged organ, these two systems interact with major consequences. Furthermore, microorganisms within their environment are major sources of stimuli and can establish relationships with animal hosts that range from pathogenic to mutualistic. Research from a variety of human and experimental animal systems are revealing that reciprocal interactions between microbiota and the nervous and immune systems contribute significantly to normal development, homeostasis, and disease. The zebrafish has emerged as an outstanding model within which to interrogate these interactions due to facile genetic and microbial manipulation and optical transparency facilitating in vivo imaging. This review summarizes recent studies that have used the zebrafish for analysis of bidirectional control between the immune and nervous systems, the nervous system and the microbiota, and the microbiota and immune system in zebrafish during development that promotes homeostasis between these systems. We also describe how the zebrafish have contributed to our understanding of the interconnections between these systems during infection in fish and how perturbations may result in pathology.

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Published In

J Neuroinflammation

DOI

EISSN

1742-2094

Publication Date

June 28, 2022

Volume

19

Issue

1

Start / End Page

170

Location

England

Related Subject Headings

  • Zebrafish
  • Neurology & Neurosurgery
  • Microbiota
  • Immune System
  • Homeostasis
  • Brain
  • Animals
  • 3209 Neurosciences
  • 3204 Immunology
  • 1109 Neurosciences
 

Citation

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ICMJE
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Levraud, J.-P., Rawls, J. F., & Clatworthy, A. E. (2022). Using zebrafish to understand reciprocal interactions between the nervous and immune systems and the microbial world. J Neuroinflammation, 19(1), 170. https://doi.org/10.1186/s12974-022-02506-x
Levraud, Jean-Pierre, John F. Rawls, and Anne E. Clatworthy. “Using zebrafish to understand reciprocal interactions between the nervous and immune systems and the microbial world.J Neuroinflammation 19, no. 1 (June 28, 2022): 170. https://doi.org/10.1186/s12974-022-02506-x.
Levraud J-P, Rawls JF, Clatworthy AE. Using zebrafish to understand reciprocal interactions between the nervous and immune systems and the microbial world. J Neuroinflammation. 2022 Jun 28;19(1):170.
Levraud, Jean-Pierre, et al. “Using zebrafish to understand reciprocal interactions between the nervous and immune systems and the microbial world.J Neuroinflammation, vol. 19, no. 1, June 2022, p. 170. Pubmed, doi:10.1186/s12974-022-02506-x.
Levraud J-P, Rawls JF, Clatworthy AE. Using zebrafish to understand reciprocal interactions between the nervous and immune systems and the microbial world. J Neuroinflammation. 2022 Jun 28;19(1):170.
Journal cover image

Published In

J Neuroinflammation

DOI

EISSN

1742-2094

Publication Date

June 28, 2022

Volume

19

Issue

1

Start / End Page

170

Location

England

Related Subject Headings

  • Zebrafish
  • Neurology & Neurosurgery
  • Microbiota
  • Immune System
  • Homeostasis
  • Brain
  • Animals
  • 3209 Neurosciences
  • 3204 Immunology
  • 1109 Neurosciences