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Cobalt(II) Diphenylazodioxide Complexes Induce Apoptosis in SK-HEP-1 Cells

Publication ,  Journal Article
Alghamdi, NJ; Balaraman, L; Emhoff, KA; Salem, AMH; Wei, R; Zhou, A; Boyd, WC
Published in: ACS Omega
September 10, 2019
Published version (DOI) Open Access Copy (Duke)

The cobalt(II) complex salts [Co(bpy)(az)2](PF6)2 and [Co(az)4](PF6), each bearing the unusual cis-N,N-diphenylazodioxide ligand, were both screened as possible anticancer agents against SK-HEP-1 liver cancer cells. Both compounds were found to induce substantial apoptosis as an increasing function of concentration and time. Measurement of apoptosis-related proteins indicated that both the extrinsic and intrinsic pathways of apoptosis were activated. The apoptotic activity induced by these salts is not displayed either by simple cobalt(II) salts or complexes or by the free nitrosobenzene ligand. Additionally, these compounds did not induce apoptosis, as assessed by poly(adenosine diphosphate-ribose) polymerase cleavage, in several other cell lines.

Duke Scholars

Ruhan Wei
Author Ruhan Wei Pathology

Published In

ACS Omega

DOI

10.1021/acsomega.9b01684

EISSN

2470-1343

Publication Date

September 10, 2019

Volume

4

Issue

11

Start / End Page

14503 / 14510

Related Subject Headings

  • 4004 Chemical engineering
  • 3406 Physical chemistry
  • 3403 Macromolecular and materials chemistry
  • 0912 Materials Engineering
  • 0904 Chemical Engineering
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Alghamdi, N. J., Balaraman, L., Emhoff, K. A., Salem, A. M. H., Wei, R., Zhou, A., & Boyd, W. C. (2019). Cobalt(II) Diphenylazodioxide Complexes Induce Apoptosis in SK-HEP-1 Cells. ACS Omega, 4(11), 14503–14510. https://doi.org/10.1021/acsomega.9b01684
Alghamdi, N. J., L. Balaraman, K. A. Emhoff, A. M. H. Salem, R. Wei, A. Zhou, and W. C. Boyd. “Cobalt(II) Diphenylazodioxide Complexes Induce Apoptosis in SK-HEP-1 Cells.” ACS Omega 4, no. 11 (September 10, 2019): 14503–10. https://doi.org/10.1021/acsomega.9b01684.
Alghamdi NJ, Balaraman L, Emhoff KA, Salem AMH, Wei R, Zhou A, et al. Cobalt(II) Diphenylazodioxide Complexes Induce Apoptosis in SK-HEP-1 Cells. ACS Omega. 2019 Sep 10;4(11):14503–10.
Alghamdi, N. J., et al. “Cobalt(II) Diphenylazodioxide Complexes Induce Apoptosis in SK-HEP-1 Cells.” ACS Omega, vol. 4, no. 11, Sept. 2019, pp. 14503–10. Scopus, doi:10.1021/acsomega.9b01684.
Alghamdi NJ, Balaraman L, Emhoff KA, Salem AMH, Wei R, Zhou A, Boyd WC. Cobalt(II) Diphenylazodioxide Complexes Induce Apoptosis in SK-HEP-1 Cells. ACS Omega. 2019 Sep 10;4(11):14503–14510.

Published In

ACS Omega

DOI

10.1021/acsomega.9b01684

EISSN

2470-1343

Publication Date

September 10, 2019

Volume

4

Issue

11

Start / End Page

14503 / 14510

Related Subject Headings

  • 4004 Chemical engineering
  • 3406 Physical chemistry
  • 3403 Macromolecular and materials chemistry
  • 0912 Materials Engineering
  • 0904 Chemical Engineering