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Leptin and its receptor are overexpressed in brain tumors and correlate with the degree of malignancy.

Publication ,  Journal Article
Riolfi, M; Ferla, R; Del Valle, L; Piña-Oviedo, S; Scolaro, L; Micciolo, R; Guidi, M; Terrasi, M; Cetto, GL; Surmacz, E
Published in: Brain Pathol
March 2010

Although leptin and its receptor (ObR) have emerged as important cancer biomarkers, the role of the leptin system in brain tumor development remains unknown. We screened 87 human brain tumor biopsies using immunohistochemistry and detected leptin and ObR in 55.2% and 60.9% cases, respectively. In contrast, leptin and ObR were absent in 14 samples of normal brain tissue. The presence of leptin correlated with ObR with overall concordance 80.5%. The leptin/ObR system was highly expressed in glioblastomas and anaplastic astrocytomas, while lower expression of both markers was noted in low-grade astrocytomas and gangliogliomas. The association between leptin/ObR and the degree of tumor malignancy was highly significant (P < 0.001). Using double immunofluorescence of glioblastoma tissues, we found co-expression of leptin with ObR and with the proliferation marker Ki-67 in 87% and 64% of cells, respectively. The leptin/ObR-positive tissues also expressed activated forms of STAT3 and Akt. In line with this finding, ObR-positive glioblastoma cells responded to leptin with cell growth and induction of the STAT3 and Akt pathways as well as inactivation of the cell cycle suppressor Rb. In summary, our data demonstrate that the leptin/ObR system is expressed in malignant brain tumors and might be involved in tumor progression.

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Published In

Brain Pathol

DOI

EISSN

1750-3639

Publication Date

March 2010

Volume

20

Issue

2

Start / End Page

481 / 489

Location

Switzerland

Related Subject Headings

  • Signal Transduction
  • STAT3 Transcription Factor
  • Receptors, Leptin
  • Oncogene Protein v-akt
  • Neurology & Neurosurgery
  • Leptin
  • Ki-67 Antigen
  • Immunohistochemistry
  • Humans
  • Glioma
 

Citation

APA
Chicago
ICMJE
MLA
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Riolfi, M., Ferla, R., Del Valle, L., Piña-Oviedo, S., Scolaro, L., Micciolo, R., … Surmacz, E. (2010). Leptin and its receptor are overexpressed in brain tumors and correlate with the degree of malignancy. Brain Pathol, 20(2), 481–489. https://doi.org/10.1111/j.1750-3639.2009.00323.x
Riolfi, Mirko, Rita Ferla, Luis Del Valle, Sergio Piña-Oviedo, Laura Scolaro, Rocco Micciolo, Micol Guidi, Marianna Terrasi, Gian Luigi Cetto, and Eva Surmacz. “Leptin and its receptor are overexpressed in brain tumors and correlate with the degree of malignancy.Brain Pathol 20, no. 2 (March 2010): 481–89. https://doi.org/10.1111/j.1750-3639.2009.00323.x.
Riolfi M, Ferla R, Del Valle L, Piña-Oviedo S, Scolaro L, Micciolo R, et al. Leptin and its receptor are overexpressed in brain tumors and correlate with the degree of malignancy. Brain Pathol. 2010 Mar;20(2):481–9.
Riolfi, Mirko, et al. “Leptin and its receptor are overexpressed in brain tumors and correlate with the degree of malignancy.Brain Pathol, vol. 20, no. 2, Mar. 2010, pp. 481–89. Pubmed, doi:10.1111/j.1750-3639.2009.00323.x.
Riolfi M, Ferla R, Del Valle L, Piña-Oviedo S, Scolaro L, Micciolo R, Guidi M, Terrasi M, Cetto GL, Surmacz E. Leptin and its receptor are overexpressed in brain tumors and correlate with the degree of malignancy. Brain Pathol. 2010 Mar;20(2):481–489.
Journal cover image

Published In

Brain Pathol

DOI

EISSN

1750-3639

Publication Date

March 2010

Volume

20

Issue

2

Start / End Page

481 / 489

Location

Switzerland

Related Subject Headings

  • Signal Transduction
  • STAT3 Transcription Factor
  • Receptors, Leptin
  • Oncogene Protein v-akt
  • Neurology & Neurosurgery
  • Leptin
  • Ki-67 Antigen
  • Immunohistochemistry
  • Humans
  • Glioma