Skip to main content
Journal cover image

HIV at 40: kidney disease in HIV treatment, prevention, and cure.

Publication ,  Journal Article
Lucas, A; Wyatt, CM
Published in: Kidney international
October 2022

Four decades after the first cases of HIV were reported, kidney disease remains an important comorbidity in people with HIV (PWH). Both HIV-associated nephropathy and immune complex kidney disease were recognized as complications of HIV infection in the early years before treatment was available. Although the introduction of effective antiretroviral therapy in the late 1990s resulted in dramatic improvements in survival and health in PWH, several commonly used antiretroviral agents have been associated with kidney injury. HIV infection and treatment may also promote the progression of comorbid chronic kidney disease due to traditional risk factors such as diabetes, and HIV is one of the strongest "second hits" for the high-risk APOL1 genotype. Unique considerations in the management of chronic kidney disease in PWH are largely related to the need for lifelong antiretroviral therapy, with potential for toxicity, drug-drug interactions, and polypharmacy. PWH who develop progressive chronic kidney disease are candidates for all modalities of kidney replacement therapy, including kidney transplantation, and at some centers, PWH may be candidates to serve as donors for recipients with HIV. Transplantation of kidney allografts from donors with HIV also offers a unique opportunity to study viral dynamics in the kidney, with implications for kidney health and for research toward HIV cure. In addition, HIV-transgenic animal models have provided important insights into kidney disease pathogenesis beyond HIV, and experience with HIV and HIV-related kidney disease has provided important lessons for future pandemics.

Duke Scholars

Altmetric Attention Stats
Dimensions Citation Stats

Published In

Kidney international

DOI

EISSN

1523-1755

ISSN

0085-2538

Publication Date

October 2022

Volume

102

Issue

4

Start / End Page

740 / 749

Related Subject Headings

  • Urology & Nephrology
  • Renal Insufficiency, Chronic
  • Humans
  • HIV Infections
  • Apolipoprotein L1
  • Antigen-Antibody Complex
  • Anti-Retroviral Agents
  • Animals
  • AIDS-Associated Nephropathy
  • 3202 Clinical sciences
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Lucas, A., & Wyatt, C. M. (2022). HIV at 40: kidney disease in HIV treatment, prevention, and cure. Kidney International, 102(4), 740–749. https://doi.org/10.1016/j.kint.2022.06.021
Lucas, Anika, and Christina M. Wyatt. “HIV at 40: kidney disease in HIV treatment, prevention, and cure.Kidney International 102, no. 4 (October 2022): 740–49. https://doi.org/10.1016/j.kint.2022.06.021.
Lucas A, Wyatt CM. HIV at 40: kidney disease in HIV treatment, prevention, and cure. Kidney international. 2022 Oct;102(4):740–9.
Lucas, Anika, and Christina M. Wyatt. “HIV at 40: kidney disease in HIV treatment, prevention, and cure.Kidney International, vol. 102, no. 4, Oct. 2022, pp. 740–49. Epmc, doi:10.1016/j.kint.2022.06.021.
Lucas A, Wyatt CM. HIV at 40: kidney disease in HIV treatment, prevention, and cure. Kidney international. 2022 Oct;102(4):740–749.
Journal cover image

Published In

Kidney international

DOI

EISSN

1523-1755

ISSN

0085-2538

Publication Date

October 2022

Volume

102

Issue

4

Start / End Page

740 / 749

Related Subject Headings

  • Urology & Nephrology
  • Renal Insufficiency, Chronic
  • Humans
  • HIV Infections
  • Apolipoprotein L1
  • Antigen-Antibody Complex
  • Anti-Retroviral Agents
  • Animals
  • AIDS-Associated Nephropathy
  • 3202 Clinical sciences