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Prenatal maternal transdiagnostic, RDoC-informed predictors of newborn neurobehavior: Differences by sex.

Publication ,  Journal Article
Gao, MM; Ostlund, B; Brown, MA; Kaliush, PR; Terrell, S; Vlisides-Henry, RD; Raby, KL; Crowell, SE; Conradt, E
Published in: Dev Psychopathol
December 2021

We examined whether Research Domain Criteria (RDoC)-informed measures of prenatal stress predicted newborn neurobehavior and whether these effects differed by newborn sex. Multilevel, prenatal markers of prenatal stress were obtained from 162 pregnant women. Markers of the Negative Valence System included physiological functioning (respiratory sinus arrhythmia [RSA] and electrodermal [EDA] reactivity to a speech task, hair cortisol), self-reported stress (state anxiety, pregnancy-specific anxiety, daily stress, childhood trauma, economic hardship, and family resources), and interviewer-rated stress (episodic stress, chronic stress). Markers of the Arousal/Regulatory System included physiological functioning (baseline RSA, RSA, and EDA responses to infant cries) and self-reported affect intensity, urgency, emotion regulation strategies, and dispositional mindfulness. Newborns' arousal and attention were assessed via the Neonatal Intensive Care Unit (NICU) Network Neurobehavioral Scale. Path analyses showed that high maternal episodic and daily stress, low economic hardship, few emotion regulation strategies, and high baseline RSA predicted female newborns' low attention; maternal mindfulness predicted female newborns' high arousal. As for male newborns, high episodic stress predicted low arousal, and high pregnancy-specific anxiety predicted high attention. Findings suggest that RDoC-informed markers of prenatal stress could aid detection of variance in newborn neurobehavioral outcomes within hours after birth. Implications for intergenerational transmission of risk for psychopathology are discussed.

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Published In

Dev Psychopathol

DOI

EISSN

1469-2198

Publication Date

December 2021

Volume

33

Issue

5

Start / End Page

1554 / 1565

Location

United States

Related Subject Headings

  • Respiratory Sinus Arrhythmia
  • Prenatal Exposure Delayed Effects
  • Pregnant Women
  • Pregnancy Complications
  • Pregnancy
  • Male
  • Infant, Newborn
  • Infant
  • Hydrocortisone
  • Humans
 

Citation

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Gao, M. M., Ostlund, B., Brown, M. A., Kaliush, P. R., Terrell, S., Vlisides-Henry, R. D., … Conradt, E. (2021). Prenatal maternal transdiagnostic, RDoC-informed predictors of newborn neurobehavior: Differences by sex. Dev Psychopathol, 33(5), 1554–1565. https://doi.org/10.1017/S0954579420002266
Gao, Mengyu Miranda, Brendan Ostlund, Mindy A. Brown, Parisa R. Kaliush, Sarah Terrell, Robert D. Vlisides-Henry, K Lee Raby, Sheila E. Crowell, and Elisabeth Conradt. “Prenatal maternal transdiagnostic, RDoC-informed predictors of newborn neurobehavior: Differences by sex.Dev Psychopathol 33, no. 5 (December 2021): 1554–65. https://doi.org/10.1017/S0954579420002266.
Gao MM, Ostlund B, Brown MA, Kaliush PR, Terrell S, Vlisides-Henry RD, et al. Prenatal maternal transdiagnostic, RDoC-informed predictors of newborn neurobehavior: Differences by sex. Dev Psychopathol. 2021 Dec;33(5):1554–65.
Gao, Mengyu Miranda, et al. “Prenatal maternal transdiagnostic, RDoC-informed predictors of newborn neurobehavior: Differences by sex.Dev Psychopathol, vol. 33, no. 5, Dec. 2021, pp. 1554–65. Pubmed, doi:10.1017/S0954579420002266.
Gao MM, Ostlund B, Brown MA, Kaliush PR, Terrell S, Vlisides-Henry RD, Raby KL, Crowell SE, Conradt E. Prenatal maternal transdiagnostic, RDoC-informed predictors of newborn neurobehavior: Differences by sex. Dev Psychopathol. 2021 Dec;33(5):1554–1565.
Journal cover image

Published In

Dev Psychopathol

DOI

EISSN

1469-2198

Publication Date

December 2021

Volume

33

Issue

5

Start / End Page

1554 / 1565

Location

United States

Related Subject Headings

  • Respiratory Sinus Arrhythmia
  • Prenatal Exposure Delayed Effects
  • Pregnant Women
  • Pregnancy Complications
  • Pregnancy
  • Male
  • Infant, Newborn
  • Infant
  • Hydrocortisone
  • Humans