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Quantitative and qualitative correlates of cervicovaginal herpes simplex virus type 2 shedding among HIV-infected women in the Women's Interagency HIV Study.

Publication ,  Journal Article
Aumakhan, B; Gange, SJ; Beyrer, C; Gaydos, CA; Minkoff, H; Merenstein, DJ; Cohen, MH; Anastos, K; Greenblatt, R; Nowicki, MJ; Quinn, TC
Published in: Int J STD AIDS
May 2011

We identified demographic, clinical and biological determinants of herpes simplex virus type 2 (HSV-2) shedding among HIV-infected participants in the Women's HIV Interagency Study (WIHS). Cervicovaginal lavage (CVL) specimens from 369 HIV-infected HSV seropositive women were tested with TaqMan polymerase chain reaction (PRC) for detection HSV-2 DNA. Seven percent of women tested positive for HSV-2 DNA in CVL. Significant correlates of the presence of HSV-2 DNA in CVL were being younger, African American or Hispanic race/ethnicity and injecting drugs in the past six months (P < 0.05). A borderline significant trend for reduced viral shedding with higher CD4+ T cell counts was observed (P = 0.08). All women who were never observed with any genital lesions and had consistently negative self-reported history of genital sores throughout the follow-up (n = 29, 8%) were negative for CVL HSV-2 DNA. HSV-2 DNA quantity was significantly associated with having frequent subsequent lesion recurrences (Spearman rho = 0.48, P = 0.016; adjusted prevalence ratio [APR] = 2.5, P = 0.012). Increasing the age of the host was inversely correlated with decreased viral shedding over time. However, a subset of older women continued to shed significant amounts of virus despite passage of time. This study provides genital HSV-2 DNA titre as a quantitative and symptom- and sign-based measures as qualitative predictors of HSV-2 shedding from the lower genital tract among HIV-infected women.

Duke Scholars

Published In

Int J STD AIDS

DOI

EISSN

1758-1052

Publication Date

May 2011

Volume

22

Issue

5

Start / End Page

273 / 277

Location

England

Related Subject Headings

  • Virus Shedding
  • Vaginal Douching
  • Risk Factors
  • Public Health
  • Polymerase Chain Reaction
  • Humans
  • Herpesvirus 2, Human
  • Herpes Genitalis
  • HIV Infections
  • Female
 

Citation

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Chicago
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Aumakhan, B., Gange, S. J., Beyrer, C., Gaydos, C. A., Minkoff, H., Merenstein, D. J., … Quinn, T. C. (2011). Quantitative and qualitative correlates of cervicovaginal herpes simplex virus type 2 shedding among HIV-infected women in the Women's Interagency HIV Study. Int J STD AIDS, 22(5), 273–277. https://doi.org/10.1258/ijsa.2009.009296
Aumakhan, B., S. J. Gange, C. Beyrer, C. A. Gaydos, H. Minkoff, D. J. Merenstein, M. H. Cohen, et al. “Quantitative and qualitative correlates of cervicovaginal herpes simplex virus type 2 shedding among HIV-infected women in the Women's Interagency HIV Study.Int J STD AIDS 22, no. 5 (May 2011): 273–77. https://doi.org/10.1258/ijsa.2009.009296.
Aumakhan B, Gange SJ, Beyrer C, Gaydos CA, Minkoff H, Merenstein DJ, et al. Quantitative and qualitative correlates of cervicovaginal herpes simplex virus type 2 shedding among HIV-infected women in the Women's Interagency HIV Study. Int J STD AIDS. 2011 May;22(5):273–7.
Aumakhan, B., et al. “Quantitative and qualitative correlates of cervicovaginal herpes simplex virus type 2 shedding among HIV-infected women in the Women's Interagency HIV Study.Int J STD AIDS, vol. 22, no. 5, May 2011, pp. 273–77. Pubmed, doi:10.1258/ijsa.2009.009296.
Aumakhan B, Gange SJ, Beyrer C, Gaydos CA, Minkoff H, Merenstein DJ, Cohen MH, Anastos K, Greenblatt R, Nowicki MJ, Quinn TC. Quantitative and qualitative correlates of cervicovaginal herpes simplex virus type 2 shedding among HIV-infected women in the Women's Interagency HIV Study. Int J STD AIDS. 2011 May;22(5):273–277.
Journal cover image

Published In

Int J STD AIDS

DOI

EISSN

1758-1052

Publication Date

May 2011

Volume

22

Issue

5

Start / End Page

273 / 277

Location

England

Related Subject Headings

  • Virus Shedding
  • Vaginal Douching
  • Risk Factors
  • Public Health
  • Polymerase Chain Reaction
  • Humans
  • Herpesvirus 2, Human
  • Herpes Genitalis
  • HIV Infections
  • Female