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Emerging HIV infections with distinct subtypes of HIV-1 infection among injection drug users from geographically separate locations in Guangxi Province, China.

Publication ,  Journal Article
Yu, XF; Chen, J; Shao, Y; Beyrer, C; Liu, B; Wang, Z; Liu, W; Yang, J; Liang, S; Viscidi, RP; Gu, J; Gurri-Glass, G; Lai, S
Published in: J Acquir Immune Defic Syndr
October 1, 1999

Heroin users from Guangxi province, a southern province of China that borders Vietnam in the south and Yunnan province in China in the west, were studied for prevalence and risk factors for HIV-1 infection. Viral env sequences from HIV-1-positive individuals were also determined for subtypes of HIV-1. The overall HIV prevalence among 227 heroin users was 40%. Most had used drugs for < or = 3 years. Sharing of injection equipment and unprotected sex were significantly associated with HIV-1 infection. Subtypes C and E HIV-1 were detected in infected heroin users and were sharply segregated in two geographic locations: only subtype C was found in a border city with Yunnan province, whereas only subtype E was found in a city bordering northern Vietnam. HIV-1 strains within each subtype were remarkably homogenous, with a mean intersubject DNA distance of 2.32% for subtype E and 1.13% for subtype C, respectively. Phylogenetic analysis of C2-V5 region of Guangxi subtype E env sequences revealed significant clustering with subtype E sequences from southern Vietnam and Cambodia. These results suggest that HIV-1 infection among heroin users in Guangxi represents two emerging epidemics initiated from distinct sources: one from Vietnam and another from Yunnan province. Factors associated with HIV-1 infection were not restricted to injection practices. Unprotected sexual behaviors are likely to increase the probability of HIV transmission beyond this high-risk population. Designing and implementing effective intervention strategies targeted toward both injection drug use and high risk sexual behavior are urgently needed to further reduce HIV-1 spread in China.

Duke Scholars

Published In

J Acquir Immune Defic Syndr

DOI

ISSN

1525-4135

Publication Date

October 1, 1999

Volume

22

Issue

2

Start / End Page

180 / 188

Location

United States

Related Subject Headings

  • Virology
  • Substance Abuse, Intravenous
  • Risk Factors
  • Prevalence
  • Polymerase Chain Reaction
  • Phylogeny
  • Molecular Sequence Data
  • Male
  • Humans
  • HIV-1
 

Citation

APA
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MLA
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Yu, X. F., Chen, J., Shao, Y., Beyrer, C., Liu, B., Wang, Z., … Lai, S. (1999). Emerging HIV infections with distinct subtypes of HIV-1 infection among injection drug users from geographically separate locations in Guangxi Province, China. J Acquir Immune Defic Syndr, 22(2), 180–188. https://doi.org/10.1097/00126334-199910010-00011
Yu, X. F., J. Chen, Y. Shao, C. Beyrer, B. Liu, Z. Wang, W. Liu, et al. “Emerging HIV infections with distinct subtypes of HIV-1 infection among injection drug users from geographically separate locations in Guangxi Province, China.J Acquir Immune Defic Syndr 22, no. 2 (October 1, 1999): 180–88. https://doi.org/10.1097/00126334-199910010-00011.
Yu XF, Chen J, Shao Y, Beyrer C, Liu B, Wang Z, et al. Emerging HIV infections with distinct subtypes of HIV-1 infection among injection drug users from geographically separate locations in Guangxi Province, China. J Acquir Immune Defic Syndr. 1999 Oct 1;22(2):180–8.
Yu, X. F., et al. “Emerging HIV infections with distinct subtypes of HIV-1 infection among injection drug users from geographically separate locations in Guangxi Province, China.J Acquir Immune Defic Syndr, vol. 22, no. 2, Oct. 1999, pp. 180–88. Pubmed, doi:10.1097/00126334-199910010-00011.
Yu XF, Chen J, Shao Y, Beyrer C, Liu B, Wang Z, Liu W, Yang J, Liang S, Viscidi RP, Gu J, Gurri-Glass G, Lai S. Emerging HIV infections with distinct subtypes of HIV-1 infection among injection drug users from geographically separate locations in Guangxi Province, China. J Acquir Immune Defic Syndr. 1999 Oct 1;22(2):180–188.

Published In

J Acquir Immune Defic Syndr

DOI

ISSN

1525-4135

Publication Date

October 1, 1999

Volume

22

Issue

2

Start / End Page

180 / 188

Location

United States

Related Subject Headings

  • Virology
  • Substance Abuse, Intravenous
  • Risk Factors
  • Prevalence
  • Polymerase Chain Reaction
  • Phylogeny
  • Molecular Sequence Data
  • Male
  • Humans
  • HIV-1