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Phenotypic and genotypic characteristics of human immunodeficiency virus type 1 from patients with AIDS in northern Thailand.

Publication ,  Journal Article
Yu, XF; Wang, Z; Beyrer, C; Celentano, DD; Khamboonruang, C; Allen, E; Nelson, K
Published in: J Virol
August 1995

Primary human immunodeficiency virus type 1 (HIV-1) isolates were obtained from 22 patients with AIDS from northern Thailand, where HIV-1 is transmitted primarily through the heterosexual route. Viral sequences were determined for the 22 patients with AIDS, and all were subtype E HIV-1 on the basis of sequence analysis of a region from the envelope protein gp120. Syncytium-inducing (SI) viruses were detected for 16 of 22 patients with AIDS by using MT-2 cells. Characteristics of amino acid sequences in V3 which have not been reported previously for subtype B SI HIV-1 were associated with the subtype E HIV-1 SI phenotype. The SI viruses from our study population contain predominantly a GPGR or GPGH motif at the tip of the V3 loop, in contrast to the previously described subtype E HIV-1 from Thailand which contained predominantly GPGQ. All the SI viruses lost a potential N-linked glycosylation site in V3 which is highly conserved among previously described subtype E HIV-1 isolates from asymptomatic patients from Thailand. HIV-1 envelope sequences including V3 from some patients with AIDS were significantly more divergent than viruses from asymptomatic patients in Thailand characterized 2 years ago or earlier. These results suggest that emergence of subtype E SI HIV-1 variants is associated with the development of AIDS, as it is for subtype B HIV-1. The divergence of subtype E HIV-1 in patients with AIDS as the disease progresses, and the divergence of subtype E HIV-1 in the infected population as the epidemic continues in Thailand, may have important implications for vaccine development.

Duke Scholars

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Published In

J Virol

DOI

ISSN

0022-538X

Publication Date

August 1995

Volume

69

Issue

8

Start / End Page

4649 / 4655

Location

United States

Related Subject Headings

  • Virology
  • Thailand
  • Sequence Homology, Amino Acid
  • Phylogeny
  • Phenotype
  • Molecular Sequence Data
  • Humans
  • HIV-1
  • Genotype
  • Amino Acid Sequence
 

Citation

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Yu, X. F., Wang, Z., Beyrer, C., Celentano, D. D., Khamboonruang, C., Allen, E., & Nelson, K. (1995). Phenotypic and genotypic characteristics of human immunodeficiency virus type 1 from patients with AIDS in northern Thailand. J Virol, 69(8), 4649–4655. https://doi.org/10.1128/JVI.69.8.4649-4655.1995
Yu, X. F., Z. Wang, C. Beyrer, D. D. Celentano, C. Khamboonruang, E. Allen, and K. Nelson. “Phenotypic and genotypic characteristics of human immunodeficiency virus type 1 from patients with AIDS in northern Thailand.J Virol 69, no. 8 (August 1995): 4649–55. https://doi.org/10.1128/JVI.69.8.4649-4655.1995.
Yu XF, Wang Z, Beyrer C, Celentano DD, Khamboonruang C, Allen E, et al. Phenotypic and genotypic characteristics of human immunodeficiency virus type 1 from patients with AIDS in northern Thailand. J Virol. 1995 Aug;69(8):4649–55.
Yu, X. F., et al. “Phenotypic and genotypic characteristics of human immunodeficiency virus type 1 from patients with AIDS in northern Thailand.J Virol, vol. 69, no. 8, Aug. 1995, pp. 4649–55. Pubmed, doi:10.1128/JVI.69.8.4649-4655.1995.
Yu XF, Wang Z, Beyrer C, Celentano DD, Khamboonruang C, Allen E, Nelson K. Phenotypic and genotypic characteristics of human immunodeficiency virus type 1 from patients with AIDS in northern Thailand. J Virol. 1995 Aug;69(8):4649–4655.

Published In

J Virol

DOI

ISSN

0022-538X

Publication Date

August 1995

Volume

69

Issue

8

Start / End Page

4649 / 4655

Location

United States

Related Subject Headings

  • Virology
  • Thailand
  • Sequence Homology, Amino Acid
  • Phylogeny
  • Phenotype
  • Molecular Sequence Data
  • Humans
  • HIV-1
  • Genotype
  • Amino Acid Sequence