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The HVTN protocol 903 vaccine preparedness study: lessons learned in preparation for HIV vaccine efficacy trials.

Publication ,  Journal Article
Djomand, G; Metch, B; Zorrilla, CD; Donastorg, Y; Casapia, M; Villafana, T; Pape, J; Figueroa, P; Hansen, M; Buchbinder, S; Beyrer, C ...
Published in: J Acquir Immune Defic Syndr
May 1, 2008

Successful recruitment and retention of HIV-uninfected at-risk participants are essential for HIV vaccine efficacy trials. A multicountry vaccine preparedness study was started in 2003 to assess enrollment and retention of HIV-negative high-risk participants and to assess their willingness to participate in future vaccine efficacy trials. HIV-negative high-risk adults were recruited in the Caribbean, in Southern Africa, and in Latin America, and were followed for 1 year. Participants included men who have sex with men, heterosexual men and women, and female sex workers. History of sexually transmitted infections and sexual risk behaviors were recorded with HIV testing at 0, 6, and 12 months, and willingness to participate in future vaccine trials was recorded at 0 and 12 months. Recruitment, retention, and willingness to participate in future trials were excellent at 3 of the 6 sites, with consistent declines in risk behaviors across cohorts over time. Although not powered to measure seroincidence, HIV seroincidence rates per 100 person-years (95% confidence interval [CI]) were as follows: 2.3 (95% CI: 0.3 to 8.2) in Botswana, 0.5 (95% CI: 0 to 2.9) in the Dominican Republic, and 3.1 (95% CI: 1.1 to 6.8) in Peru. The HIV Vaccine Trials Network 903 study helped to develop clinical trial site capacity, with a focus on recruitment and retention of high-risk women in the Americas, and improved network and site expertise about large-scale HIV vaccine efficacy trials.

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Published In

J Acquir Immune Defic Syndr

DOI

ISSN

1525-4135

Publication Date

May 1, 2008

Volume

48

Issue

1

Start / End Page

82 / 89

Location

United States

Related Subject Headings

  • Virology
  • Sexual Behavior
  • Male
  • Humans
  • HIV Infections
  • Female
  • Cohort Studies
  • Adult
  • Adolescent
  • AIDS Vaccines
 

Citation

APA
Chicago
ICMJE
MLA
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Djomand, G., Metch, B., Zorrilla, C. D., Donastorg, Y., Casapia, M., Villafana, T., … 903 Protocol Team, . (2008). The HVTN protocol 903 vaccine preparedness study: lessons learned in preparation for HIV vaccine efficacy trials. J Acquir Immune Defic Syndr, 48(1), 82–89. https://doi.org/10.1097/QAI.0b013e31817236ab
Djomand, Gaston, Barbara Metch, Carmen D. Zorrilla, Yeycy Donastorg, Martin Casapia, Tonya Villafana, Jean Pape, et al. “The HVTN protocol 903 vaccine preparedness study: lessons learned in preparation for HIV vaccine efficacy trials.J Acquir Immune Defic Syndr 48, no. 1 (May 1, 2008): 82–89. https://doi.org/10.1097/QAI.0b013e31817236ab.
Djomand G, Metch B, Zorrilla CD, Donastorg Y, Casapia M, Villafana T, et al. The HVTN protocol 903 vaccine preparedness study: lessons learned in preparation for HIV vaccine efficacy trials. J Acquir Immune Defic Syndr. 2008 May 1;48(1):82–9.
Djomand, Gaston, et al. “The HVTN protocol 903 vaccine preparedness study: lessons learned in preparation for HIV vaccine efficacy trials.J Acquir Immune Defic Syndr, vol. 48, no. 1, May 2008, pp. 82–89. Pubmed, doi:10.1097/QAI.0b013e31817236ab.
Djomand G, Metch B, Zorrilla CD, Donastorg Y, Casapia M, Villafana T, Pape J, Figueroa P, Hansen M, Buchbinder S, Beyrer C, 903 Protocol Team. The HVTN protocol 903 vaccine preparedness study: lessons learned in preparation for HIV vaccine efficacy trials. J Acquir Immune Defic Syndr. 2008 May 1;48(1):82–89.

Published In

J Acquir Immune Defic Syndr

DOI

ISSN

1525-4135

Publication Date

May 1, 2008

Volume

48

Issue

1

Start / End Page

82 / 89

Location

United States

Related Subject Headings

  • Virology
  • Sexual Behavior
  • Male
  • Humans
  • HIV Infections
  • Female
  • Cohort Studies
  • Adult
  • Adolescent
  • AIDS Vaccines