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Immune correlates of HIV-1 reservoir cell decline in early-treated infants.

Publication ,  Journal Article
Hartana, CA; Garcia-Broncano, P; Rassadkina, Y; Lian, X; Jiang, C; Einkauf, KB; Maswabi, K; Ajibola, G; Moyo, S; Mohammed, T; Maphorisa, C ...
Published in: Cell reports
July 2022

Initiation of antiretroviral therapy (ART) in infected neonates within hours after birth limits viral reservoir seeding but does not prevent long-term HIV-1 persistence. Here, we report parallel assessments of HIV-1 reservoir cells and innate antiviral immune responses in a unique cohort of 37 infected neonates from Botswana who started ART extremely early, frequently within hours after birth. Decline of genome-intact HIV-1 proviruses occurs rapidly after initiation of ART and is associated with an increase in natural killer (NK) cell populations expressing the cytotoxicity marker CD57 and with a decrease in NK cell subsets expressing the inhibitory marker NKG2A. Immune perturbations in innate lymphoid cells, myeloid dendritic cells, and monocytes detected at birth normalize after rapid institution of antiretroviral therapy but do not notably influence HIV-1 reservoir cell dynamics. These results suggest that HIV-1 reservoir cell seeding and evolution in early-treated neonates is markedly influenced by antiviral NK cell immune responses.

Duke Scholars

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Published In

Cell reports

DOI

EISSN

2211-1247

ISSN

2211-1247

Publication Date

July 2022

Volume

40

Issue

3

Start / End Page

111126

Related Subject Headings

  • Killer Cells, Natural
  • Infant, Newborn
  • Immunity, Innate
  • Humans
  • HIV-1
  • HIV Seropositivity
  • HIV Infections
  • CD4-Positive T-Lymphocytes
  • Antiviral Agents
  • 31 Biological sciences
 

Citation

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Hartana, C. A., Garcia-Broncano, P., Rassadkina, Y., Lian, X., Jiang, C., Einkauf, K. B., … Lichterfeld, M. (2022). Immune correlates of HIV-1 reservoir cell decline in early-treated infants. Cell Reports, 40(3), 111126. https://doi.org/10.1016/j.celrep.2022.111126
Hartana, Ciputra Adijaya, Pilar Garcia-Broncano, Yelizaveta Rassadkina, Xiaodong Lian, Chenyang Jiang, Kevin B. Einkauf, Kenneth Maswabi, et al. “Immune correlates of HIV-1 reservoir cell decline in early-treated infants.Cell Reports 40, no. 3 (July 2022): 111126. https://doi.org/10.1016/j.celrep.2022.111126.
Hartana CA, Garcia-Broncano P, Rassadkina Y, Lian X, Jiang C, Einkauf KB, et al. Immune correlates of HIV-1 reservoir cell decline in early-treated infants. Cell reports. 2022 Jul;40(3):111126.
Hartana, Ciputra Adijaya, et al. “Immune correlates of HIV-1 reservoir cell decline in early-treated infants.Cell Reports, vol. 40, no. 3, July 2022, p. 111126. Epmc, doi:10.1016/j.celrep.2022.111126.
Hartana CA, Garcia-Broncano P, Rassadkina Y, Lian X, Jiang C, Einkauf KB, Maswabi K, Ajibola G, Moyo S, Mohammed T, Maphorisa C, Makhema J, Yuki Y, Martin M, Bennett K, Jean-Philippe P, Viard M, Hughes MD, Powis KM, Carrington M, Lockman S, Gao C, Yu XG, Kuritzkes DR, Shapiro R, Lichterfeld M. Immune correlates of HIV-1 reservoir cell decline in early-treated infants. Cell reports. 2022 Jul;40(3):111126.
Journal cover image

Published In

Cell reports

DOI

EISSN

2211-1247

ISSN

2211-1247

Publication Date

July 2022

Volume

40

Issue

3

Start / End Page

111126

Related Subject Headings

  • Killer Cells, Natural
  • Infant, Newborn
  • Immunity, Innate
  • Humans
  • HIV-1
  • HIV Seropositivity
  • HIV Infections
  • CD4-Positive T-Lymphocytes
  • Antiviral Agents
  • 31 Biological sciences