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Sex-biased admixture and assortative mating shape genetic variation and influence demographic inference in admixed Cabo Verdeans.

Publication ,  Journal Article
Korunes, KL; Soares-Souza, GB; Bobrek, K; Tang, H; Araújo, II; Goldberg, A; Beleza, S
Published in: G3 (Bethesda, Md.)
September 2022

Genetic data can provide insights into population history, but first, we must understand the patterns that complex histories leave in genomes. Here, we consider the admixed human population of Cabo Verde to understand the patterns of genetic variation left by social and demographic processes. First settled in the late 1400s, Cabo Verdeans are admixed descendants of Portuguese colonizers and enslaved West African people. We consider Cabo Verde's well-studied historical record alongside genome-wide SNP data from 563 individuals from 4 regions within the archipelago. We use genetic ancestry to test for patterns of nonrandom mating and sex-specific gene flow, and we examine the consequences of these processes for common demographic inference methods and genetic patterns. Notably, multiple population genetic tools that assume random mating underestimate the timing of admixture, but incorporating nonrandom mating produces estimates more consistent with historical records. We consider how admixture interrupts common summaries of genomic variation such as runs of homozygosity. While summaries of runs of homozygosity may be difficult to interpret in admixed populations, differentiating runs of homozygosity by length class shows that runs of homozygosity reflect historical differences between the islands in their contributions from the source populations and postadmixture population dynamics. Finally, we find higher African ancestry on the X chromosome than on the autosomes, consistent with an excess of European males and African females contributing to the gene pool. Considering these genomic insights into population history in the context of Cabo Verde's historical record, we can identify how assumptions in genetic models impact inference of population history more broadly.

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Published In

G3 (Bethesda, Md.)

DOI

EISSN

2160-1836

ISSN

2160-1836

Publication Date

September 2022

Volume

12

Issue

10

Start / End Page

jkac183

Related Subject Headings

  • Male
  • Humans
  • Genetics, Population
  • Genetic Variation
  • Female
  • Demography
  • Cabo Verde
  • Black People
  • 4905 Statistics
  • 3105 Genetics
 

Citation

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Korunes, K. L., Soares-Souza, G. B., Bobrek, K., Tang, H., Araújo, I. I., Goldberg, A., & Beleza, S. (2022). Sex-biased admixture and assortative mating shape genetic variation and influence demographic inference in admixed Cabo Verdeans. G3 (Bethesda, Md.), 12(10), jkac183. https://doi.org/10.1093/g3journal/jkac183
Korunes, Katharine L., Giordano Bruno Soares-Souza, Katherine Bobrek, Hua Tang, Isabel Inês Araújo, Amy Goldberg, and Sandra Beleza. “Sex-biased admixture and assortative mating shape genetic variation and influence demographic inference in admixed Cabo Verdeans.G3 (Bethesda, Md.) 12, no. 10 (September 2022): jkac183. https://doi.org/10.1093/g3journal/jkac183.
Korunes KL, Soares-Souza GB, Bobrek K, Tang H, Araújo II, Goldberg A, et al. Sex-biased admixture and assortative mating shape genetic variation and influence demographic inference in admixed Cabo Verdeans. G3 (Bethesda, Md). 2022 Sep;12(10):jkac183.
Korunes, Katharine L., et al. “Sex-biased admixture and assortative mating shape genetic variation and influence demographic inference in admixed Cabo Verdeans.G3 (Bethesda, Md.), vol. 12, no. 10, Sept. 2022, p. jkac183. Epmc, doi:10.1093/g3journal/jkac183.
Korunes KL, Soares-Souza GB, Bobrek K, Tang H, Araújo II, Goldberg A, Beleza S. Sex-biased admixture and assortative mating shape genetic variation and influence demographic inference in admixed Cabo Verdeans. G3 (Bethesda, Md). 2022 Sep;12(10):jkac183.

Published In

G3 (Bethesda, Md.)

DOI

EISSN

2160-1836

ISSN

2160-1836

Publication Date

September 2022

Volume

12

Issue

10

Start / End Page

jkac183

Related Subject Headings

  • Male
  • Humans
  • Genetics, Population
  • Genetic Variation
  • Female
  • Demography
  • Cabo Verde
  • Black People
  • 4905 Statistics
  • 3105 Genetics