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To D or not to D: vitamin D in hematopoietic cell transplantation.

Publication ,  Journal Article
Hong, S; Ferraro, CS; Hamilton, BK; Majhail, NS
Published in: Bone Marrow Transplant
November 2020

Vitamin D plays an essential role in bone health, immune tolerance, and immune modulation. Autologous and allogeneic hematopoietic cell transplantation (HCT) recipients are at increased risk of vitamin D deficiency, which may increase risks of bone loss and fracture, graft-versus-host disease (GVHD), and relapse, and can delay hematologic and immune recovery following HCT. Growing evidence indicates that vitamin D may have a role as an immunomodulator, and supplementation during HCT may decrease the risk of GVHD, infection, relapse, and mortality. In this paper, we review the role of vitamin D and its association with HCT outcomes and discuss prevention and treatment of vitamin D deficiency after HCT in adult recipients. We review the role of monitoring of vitamin D levels pre- and post-HCT and its supplementation in appropriate patients. We also review the use of bone densitometry prior to HCT and in long-term follow-up and the treatment of osteoporosis in this high-risk population.

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Published In

Bone Marrow Transplant

DOI

EISSN

1476-5365

Publication Date

November 2020

Volume

55

Issue

11

Start / End Page

2060 / 2070

Location

England

Related Subject Headings

  • Vitamin D Deficiency
  • Vitamin D
  • Transplantation, Homologous
  • Immunology
  • Humans
  • Hematopoietic Stem Cell Transplantation
  • Graft vs Host Disease
  • Adult
  • 3211 Oncology and carcinogenesis
  • 3201 Cardiovascular medicine and haematology
 

Citation

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Hong, S., Ferraro, C. S., Hamilton, B. K., & Majhail, N. S. (2020). To D or not to D: vitamin D in hematopoietic cell transplantation. Bone Marrow Transplant, 55(11), 2060–2070. https://doi.org/10.1038/s41409-020-0904-7
Hong, Sanghee, Christina S. Ferraro, Betty K. Hamilton, and Navneet S. Majhail. “To D or not to D: vitamin D in hematopoietic cell transplantation.Bone Marrow Transplant 55, no. 11 (November 2020): 2060–70. https://doi.org/10.1038/s41409-020-0904-7.
Hong S, Ferraro CS, Hamilton BK, Majhail NS. To D or not to D: vitamin D in hematopoietic cell transplantation. Bone Marrow Transplant. 2020 Nov;55(11):2060–70.
Hong, Sanghee, et al. “To D or not to D: vitamin D in hematopoietic cell transplantation.Bone Marrow Transplant, vol. 55, no. 11, Nov. 2020, pp. 2060–70. Pubmed, doi:10.1038/s41409-020-0904-7.
Hong S, Ferraro CS, Hamilton BK, Majhail NS. To D or not to D: vitamin D in hematopoietic cell transplantation. Bone Marrow Transplant. 2020 Nov;55(11):2060–2070.

Published In

Bone Marrow Transplant

DOI

EISSN

1476-5365

Publication Date

November 2020

Volume

55

Issue

11

Start / End Page

2060 / 2070

Location

England

Related Subject Headings

  • Vitamin D Deficiency
  • Vitamin D
  • Transplantation, Homologous
  • Immunology
  • Humans
  • Hematopoietic Stem Cell Transplantation
  • Graft vs Host Disease
  • Adult
  • 3211 Oncology and carcinogenesis
  • 3201 Cardiovascular medicine and haematology