Skip to main content

Psychosocial Assessment of Candidates for Transplant (PACT) as a tool for psychological and social evaluation of allogeneic hematopoietic cell transplantation recipients.

Publication ,  Journal Article
Hong, S; Rybicki, L; Corrigan, D; Dabney, J; Hamilton, BK; Kalaycio, M; Lawrence, C; McLellan, L; Sobecks, R; Lee, SJ; Majhail, NS
Published in: Bone Marrow Transplant
September 2019

Psychosocial Assessment of Candidates for Transplant (PACT) is a tool originally developed to address psychosocial risks in solid organ transplant recipients and has the potential for application to hematopoietic cell transplantation (HCT) recipients. In a retrospective cohort study, we reviewed 404 adult allogeneic HCT cases from 2003 to 2014 to identify predictors of adverse psychosocial status as determined by PACT. Final PACT rating was poor/borderline (score 0-1) in 5%, acceptable (score 2) in 22%, good (score 3) in 44%, and excellent (score 4) in 29% recipients. In multivariable regression, higher PACT score was associated with White race (odds ratio [OR] 2.95, P < 0.001), having a related donor (OR 1.61, P = 0.015), and a higher quality of life score (OR 1.22/ 10-point increase in FACT-BMT total score, P < 0.001). PACT score correlated with all quality of life subscales. The final PACT score was associated with non-relapse mortality (HR 0.82/ 1-point increase, p = 0.03) in multivariable analysis that considered patient and disease factors, but not in models that also included transplant-related factors and performance status. PACT score was not associated with overall survival. PACT can be considered as part of a comprehensive psychosocial assessment for identifying patients who may require additional resources around allogeneic HCT.

Duke Scholars

Altmetric Attention Stats
Dimensions Citation Stats

Published In

Bone Marrow Transplant

DOI

EISSN

1476-5365

Publication Date

September 2019

Volume

54

Issue

9

Start / End Page

1443 / 1452

Location

England

Related Subject Headings

  • White People
  • Unrelated Donors
  • Risk Factors
  • Risk Assessment
  • Retrospective Studies
  • Quality of Life
  • Predictive Value of Tests
  • Middle Aged
  • Male
  • Immunology
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Hong, S., Rybicki, L., Corrigan, D., Dabney, J., Hamilton, B. K., Kalaycio, M., … Majhail, N. S. (2019). Psychosocial Assessment of Candidates for Transplant (PACT) as a tool for psychological and social evaluation of allogeneic hematopoietic cell transplantation recipients. Bone Marrow Transplant, 54(9), 1443–1452. https://doi.org/10.1038/s41409-019-0455-y
Hong, Sanghee, Lisa Rybicki, Donna Corrigan, Jane Dabney, Betty K. Hamilton, Matt Kalaycio, Christine Lawrence, et al. “Psychosocial Assessment of Candidates for Transplant (PACT) as a tool for psychological and social evaluation of allogeneic hematopoietic cell transplantation recipients.Bone Marrow Transplant 54, no. 9 (September 2019): 1443–52. https://doi.org/10.1038/s41409-019-0455-y.
Hong S, Rybicki L, Corrigan D, Dabney J, Hamilton BK, Kalaycio M, et al. Psychosocial Assessment of Candidates for Transplant (PACT) as a tool for psychological and social evaluation of allogeneic hematopoietic cell transplantation recipients. Bone Marrow Transplant. 2019 Sep;54(9):1443–52.
Hong, Sanghee, et al. “Psychosocial Assessment of Candidates for Transplant (PACT) as a tool for psychological and social evaluation of allogeneic hematopoietic cell transplantation recipients.Bone Marrow Transplant, vol. 54, no. 9, Sept. 2019, pp. 1443–52. Pubmed, doi:10.1038/s41409-019-0455-y.
Hong S, Rybicki L, Corrigan D, Dabney J, Hamilton BK, Kalaycio M, Lawrence C, McLellan L, Sobecks R, Lee SJ, Majhail NS. Psychosocial Assessment of Candidates for Transplant (PACT) as a tool for psychological and social evaluation of allogeneic hematopoietic cell transplantation recipients. Bone Marrow Transplant. 2019 Sep;54(9):1443–1452.

Published In

Bone Marrow Transplant

DOI

EISSN

1476-5365

Publication Date

September 2019

Volume

54

Issue

9

Start / End Page

1443 / 1452

Location

England

Related Subject Headings

  • White People
  • Unrelated Donors
  • Risk Factors
  • Risk Assessment
  • Retrospective Studies
  • Quality of Life
  • Predictive Value of Tests
  • Middle Aged
  • Male
  • Immunology