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Dynamic susceptibility contrast MRI with localized arterial input functions.

Publication ,  Journal Article
Lee, JJ; Bretthorst, GL; Derdeyn, CP; Powers, WJ; Videen, TO; Snyder, AZ; Markham, J; Shimony, JS
Published in: Magn Reson Med
May 2010

Compared to gold-standard measurements of cerebral perfusion with positron emission tomography using H(2)[(15)O] tracers, measurements with dynamic susceptibility contrast MR are more accessible, less expensive, and less invasive. However, existing methods for analyzing and interpreting data from dynamic susceptibility contrast MR have characteristic disadvantages that include sensitivity to incorrectly modeled delay and dispersion in a single, global arterial input function. We describe a model of tissue microcirculation derived from tracer kinetics that estimates for each voxel a unique, localized arterial input function. Parameters of the model were estimated using Bayesian probability theory and Markov-chain Monte Carlo, circumventing difficulties arising from numerical deconvolution. Applying the new method to imaging studies from a cohort of 14 patients with chronic, atherosclerotic, occlusive disease showed strong correlations between perfusion measured by dynamic susceptibility contrast MR with localized arterial input function and perfusion measured by quantitative positron emission tomography with H(2)[(15)O]. Regression to positron emission tomography measurements enabled conversion of dynamic susceptibility contrast MR to a physiologic scale. Regression analysis for localized arterial input function gave estimates of a scaling factor for quantitation that described perfusion accurately in patients with substantial variability in hemodynamic impairment.

Duke Scholars

Published In

Magn Reson Med

DOI

EISSN

1522-2594

Publication Date

May 2010

Volume

63

Issue

5

Start / End Page

1305 / 1314

Location

United States

Related Subject Headings

  • Sensitivity and Specificity
  • Reproducibility of Results
  • Radionuclide Imaging
  • Nuclear Medicine & Medical Imaging
  • Magnetic Resonance Angiography
  • Image Interpretation, Computer-Assisted
  • Image Enhancement
  • Humans
  • Gadolinium DTPA
  • Contrast Media
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Lee, J. J., Bretthorst, G. L., Derdeyn, C. P., Powers, W. J., Videen, T. O., Snyder, A. Z., … Shimony, J. S. (2010). Dynamic susceptibility contrast MRI with localized arterial input functions. Magn Reson Med, 63(5), 1305–1314. https://doi.org/10.1002/mrm.22338
Lee, John J., G Larry Bretthorst, Colin P. Derdeyn, William J. Powers, Tom O. Videen, Abraham Z. Snyder, Joanne Markham, and Joshua S. Shimony. “Dynamic susceptibility contrast MRI with localized arterial input functions.Magn Reson Med 63, no. 5 (May 2010): 1305–14. https://doi.org/10.1002/mrm.22338.
Lee JJ, Bretthorst GL, Derdeyn CP, Powers WJ, Videen TO, Snyder AZ, et al. Dynamic susceptibility contrast MRI with localized arterial input functions. Magn Reson Med. 2010 May;63(5):1305–14.
Lee, John J., et al. “Dynamic susceptibility contrast MRI with localized arterial input functions.Magn Reson Med, vol. 63, no. 5, May 2010, pp. 1305–14. Pubmed, doi:10.1002/mrm.22338.
Lee JJ, Bretthorst GL, Derdeyn CP, Powers WJ, Videen TO, Snyder AZ, Markham J, Shimony JS. Dynamic susceptibility contrast MRI with localized arterial input functions. Magn Reson Med. 2010 May;63(5):1305–1314.
Journal cover image

Published In

Magn Reson Med

DOI

EISSN

1522-2594

Publication Date

May 2010

Volume

63

Issue

5

Start / End Page

1305 / 1314

Location

United States

Related Subject Headings

  • Sensitivity and Specificity
  • Reproducibility of Results
  • Radionuclide Imaging
  • Nuclear Medicine & Medical Imaging
  • Magnetic Resonance Angiography
  • Image Interpretation, Computer-Assisted
  • Image Enhancement
  • Humans
  • Gadolinium DTPA
  • Contrast Media