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Phase separation of chromatin and small RNA pathways in plants.

Publication ,  Journal Article
Lei, Z; Wang, L; Kim, EY; Cho, J
Published in: The Plant Journal : for Cell and Molecular Biology
December 2021

Gene expression can be modulated by epigenetic mechanisms, including chromatin modifications and small regulatory RNAs. These pathways are unevenly distributed within a cell and usually take place in specific intracellular regions. Unfortunately, the fundamental driving force and biological relevance of such spatial differentiation is largely unknown. Liquid-liquid phase separation (LLPS) is a natural propensity of demixing liquid phases and has been recently suggested to mediate the formation of biomolecular condensates that are relevant to diverse cellular processes. LLPS provides a mechanistic explanation for the self-assembly of subcellular structures by which the efficiency and specificity of certain cellular reactions are achieved. In plants, LLPS has been observed for several key factors in the chromatin and small RNA pathways. For example, the formation of facultative and obligate heterochromatin involves the LLPS of multiple relevant factors. In addition, phase separation is observed in a set of proteins acting in microRNA biogenesis and the small interfering RNA pathway. In this Focused Review, we highlight and discuss the recent findings regarding phase separation in the epigenetic mechanisms of plants.

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Published In

The Plant Journal : for Cell and Molecular Biology

DOI

EISSN

1365-313X

ISSN

0960-7412

Publication Date

December 2021

Volume

108

Issue

5

Start / End Page

1256 / 1265

Related Subject Headings

  • RNA, Small Interfering
  • RNA, Plant
  • Plants
  • Plant Proteins
  • Plant Biology & Botany
  • MicroRNAs
  • Heterochromatin
  • Epigenesis, Genetic
  • Chromatin
  • Biomolecular Condensates
 

Citation

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Lei, Z., Wang, L., Kim, E. Y., & Cho, J. (2021). Phase separation of chromatin and small RNA pathways in plants. The Plant Journal : For Cell and Molecular Biology, 108(5), 1256–1265. https://doi.org/10.1111/tpj.15517
Lei, Zhen, Ling Wang, Eun Yu Kim, and Jungnam Cho. “Phase separation of chromatin and small RNA pathways in plants.The Plant Journal : For Cell and Molecular Biology 108, no. 5 (December 2021): 1256–65. https://doi.org/10.1111/tpj.15517.
Lei Z, Wang L, Kim EY, Cho J. Phase separation of chromatin and small RNA pathways in plants. The Plant Journal : for Cell and Molecular Biology. 2021 Dec;108(5):1256–65.
Lei, Zhen, et al. “Phase separation of chromatin and small RNA pathways in plants.The Plant Journal : For Cell and Molecular Biology, vol. 108, no. 5, Dec. 2021, pp. 1256–65. Epmc, doi:10.1111/tpj.15517.
Lei Z, Wang L, Kim EY, Cho J. Phase separation of chromatin and small RNA pathways in plants. The Plant Journal : for Cell and Molecular Biology. 2021 Dec;108(5):1256–1265.
Journal cover image

Published In

The Plant Journal : for Cell and Molecular Biology

DOI

EISSN

1365-313X

ISSN

0960-7412

Publication Date

December 2021

Volume

108

Issue

5

Start / End Page

1256 / 1265

Related Subject Headings

  • RNA, Small Interfering
  • RNA, Plant
  • Plants
  • Plant Proteins
  • Plant Biology & Botany
  • MicroRNAs
  • Heterochromatin
  • Epigenesis, Genetic
  • Chromatin
  • Biomolecular Condensates