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Novel emboli protection cannula during cardiac surgery: first animal study.

Publication ,  Journal Article
Shani, L; Cohen, O; Beckerman, Z; Nir, R-R; Bolotin, G
Published in: Asian Cardiovasc Thorac Ann
January 2014

BACKGROUND: Stroke after open heart surgery is a major cause of morbidity and mortality. Up to 60% of intraoperative cerebral events are caused by emboli generated by manipulations of the aorta during surgery. This is the first animal study evaluating the safety and efficacy of a novel aortic cannula designed to extract solid and gaseous emboli during cardiac surgery. METHODS: Seven domestic pigs were connected to cardiopulmonary bypass using a CardioGard 24F aortic cannula. Three pigs that were cannulated with a standard aortic cannula were defined as controls. Several main flow and suction regimens were carried out. Osseous particles of different sizes were injected into the proximal aorta to simulate emboli. RESULTS: The CardioGard cannula demonstrated an overall emboli retrieval rate of 77%. A rate of 88.45% was demonstrated during the low-flow regimen used clinically during aortic manipulation. Gaseous and solid emboli were eliminated by suction, as demonstrated by epi-carotid ultrasound. No significant changes were observed in hemodynamic and laboratory parameters. CONCLUSIONS: The CardioGard cannula is as simple to use as a regular commercially available aortic cannula, having a similar safety profile and proven efficacy in capturing intraoperative emboli.

Duke Scholars

Published In

Asian Cardiovasc Thorac Ann

DOI

EISSN

1816-5370

Publication Date

January 2014

Volume

22

Issue

1

Start / End Page

25 / 30

Location

England

Related Subject Headings

  • Vascular Access Devices
  • Ultrasonography
  • Sus scrofa
  • Respiratory System
  • Regional Blood Flow
  • Prosthesis Design
  • Models, Animal
  • Hemodynamics
  • Embolism
  • Embolic Protection Devices
 

Citation

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Shani, L., Cohen, O., Beckerman, Z., Nir, R.-R., & Bolotin, G. (2014). Novel emboli protection cannula during cardiac surgery: first animal study. Asian Cardiovasc Thorac Ann, 22(1), 25–30. https://doi.org/10.1177/0218492312467543
Shani, Liran, Oved Cohen, Ziv Beckerman, Rony-Reuven Nir, and Gil Bolotin. “Novel emboli protection cannula during cardiac surgery: first animal study.Asian Cardiovasc Thorac Ann 22, no. 1 (January 2014): 25–30. https://doi.org/10.1177/0218492312467543.
Shani L, Cohen O, Beckerman Z, Nir R-R, Bolotin G. Novel emboli protection cannula during cardiac surgery: first animal study. Asian Cardiovasc Thorac Ann. 2014 Jan;22(1):25–30.
Shani, Liran, et al. “Novel emboli protection cannula during cardiac surgery: first animal study.Asian Cardiovasc Thorac Ann, vol. 22, no. 1, Jan. 2014, pp. 25–30. Pubmed, doi:10.1177/0218492312467543.
Shani L, Cohen O, Beckerman Z, Nir R-R, Bolotin G. Novel emboli protection cannula during cardiac surgery: first animal study. Asian Cardiovasc Thorac Ann. 2014 Jan;22(1):25–30.
Journal cover image

Published In

Asian Cardiovasc Thorac Ann

DOI

EISSN

1816-5370

Publication Date

January 2014

Volume

22

Issue

1

Start / End Page

25 / 30

Location

England

Related Subject Headings

  • Vascular Access Devices
  • Ultrasonography
  • Sus scrofa
  • Respiratory System
  • Regional Blood Flow
  • Prosthesis Design
  • Models, Animal
  • Hemodynamics
  • Embolism
  • Embolic Protection Devices