Skip to main content

Engineering Three-Dimensional Vascularized Cardiac Tissues.

Publication ,  Journal Article
Williams, MAC; Mair, DB; Lee, W; Lee, E; Kim, D-H
Published in: Tissue Eng Part B Rev
April 2022

Heart disease is one of the largest burdens to human health worldwide and has very limited therapeutic options. Engineered three-dimensional (3D) vascularized cardiac tissues have shown promise in rescuing cardiac function in diseased hearts and may serve as a whole organ replacement in the future. One of the major obstacles in reconstructing these thick myocardial tissues to a clinically applicable scale is the integration of functional vascular networks capable of providing oxygen and nutrients throughout whole engineered constructs. Without perfusion of oxygen and nutrient flow throughout the entire engineered tissue not only is tissue viability compromised, but also overall tissue functionality is lost. There are many supporting technologies and approaches that have been developed to create vascular networks such as 3D bioprinting, co-culturing hydrogels, and incorporation of soluble angiogenic factors. In this state-of-the-art review, we discuss some of the most current engineered vascular cardiac tissues reported in the literature and future directions in the field. Impact statement The field of cardiac tissue engineering is rapidly evolving and is now closer than ever to having engineered tissue models capable of predicting preclinical responses to therapeutics, modeling diseases, and being used as a means of rescuing cardiac function following injuries to the native myocardium. However, a major obstacle of engineering thick cardiac tissue remains to be the integration of functional vasculature. In this review, we highlight seminal and recently published works that have influenced and pushed the field of cardiac tissue engineering toward achieving vascularized functional tissues.

Duke Scholars

Altmetric Attention Stats
Dimensions Citation Stats

Published In

Tissue Eng Part B Rev

DOI

EISSN

1937-3376

Publication Date

April 2022

Volume

28

Issue

2

Start / End Page

336 / 350

Location

United States

Related Subject Headings

  • Tissue Engineering
  • Oxygen
  • Myocardium
  • Hydrogels
  • Humans
  • Bioprinting
  • Biomedical Engineering
  • 4003 Biomedical engineering
  • 0903 Biomedical Engineering
  • 0601 Biochemistry and Cell Biology
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Williams, M. A. C., Mair, D. B., Lee, W., Lee, E., & Kim, D.-H. (2022). Engineering Three-Dimensional Vascularized Cardiac Tissues. Tissue Eng Part B Rev, 28(2), 336–350. https://doi.org/10.1089/ten.TEB.2020.0343
Williams, Marcus Alonso Cee, Devin B. Mair, Wonjae Lee, Esak Lee, and Deok-Ho Kim. “Engineering Three-Dimensional Vascularized Cardiac Tissues.Tissue Eng Part B Rev 28, no. 2 (April 2022): 336–50. https://doi.org/10.1089/ten.TEB.2020.0343.
Williams MAC, Mair DB, Lee W, Lee E, Kim D-H. Engineering Three-Dimensional Vascularized Cardiac Tissues. Tissue Eng Part B Rev. 2022 Apr;28(2):336–50.
Williams, Marcus Alonso Cee, et al. “Engineering Three-Dimensional Vascularized Cardiac Tissues.Tissue Eng Part B Rev, vol. 28, no. 2, Apr. 2022, pp. 336–50. Pubmed, doi:10.1089/ten.TEB.2020.0343.
Williams MAC, Mair DB, Lee W, Lee E, Kim D-H. Engineering Three-Dimensional Vascularized Cardiac Tissues. Tissue Eng Part B Rev. 2022 Apr;28(2):336–350.

Published In

Tissue Eng Part B Rev

DOI

EISSN

1937-3376

Publication Date

April 2022

Volume

28

Issue

2

Start / End Page

336 / 350

Location

United States

Related Subject Headings

  • Tissue Engineering
  • Oxygen
  • Myocardium
  • Hydrogels
  • Humans
  • Bioprinting
  • Biomedical Engineering
  • 4003 Biomedical engineering
  • 0903 Biomedical Engineering
  • 0601 Biochemistry and Cell Biology