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Hydrophobic nanoparticles improve permeability of cell-encapsulating poly(ethylene glycol) hydrogels while maintaining patternability.

Publication ,  Journal Article
Lee, W; Cho, N-J; Xiong, A; Glenn, JS; Frank, CW
Published in: Proc Natl Acad Sci U S A
November 30, 2010

Cell encapsulating poly(ethylene glycol) hydrogels represent a promising approach for constructing 3D cultures designed to more closely approximate in vivo tissue environment. Improved strategies are needed, however, to optimally balance hydrogel permeability to support metabolic activities of encapsulated cells, while maintaining patternability to restore key aspects of tissue architecture. Herein, we have developed one such strategy incorporating hydrophobic nanoparticles to partially induce looser cross-linking density at the particle-hydrogel interface. Strikingly, our network design significantly increased hydrogel permeability, while only minimally affecting the matrix mechanical strength or prepolymer viscosity. This structural advantage improved viability and functions of encapsulated cells and permitted micron-scale structures to control over spatial distribution of incorporated cells. We expect that this design strategy holds promise for the development of more advanced artificial tissues that can promote high levels of cell metabolic activity and recapitulate key architectural features.

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Published In

Proc Natl Acad Sci U S A

DOI

EISSN

1091-6490

Publication Date

November 30, 2010

Volume

107

Issue

48

Start / End Page

20709 / 20714

Location

United States

Related Subject Headings

  • Viscosity
  • Reference Standards
  • Polylactic Acid-Polyglycolic Acid Copolymer
  • Polyglycolic Acid
  • Polyethylene Glycols
  • Phenotype
  • Nanoparticles
  • Molecular Weight
  • Materials Testing
  • Lactic Acid
 

Citation

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Lee, W., Cho, N.-J., Xiong, A., Glenn, J. S., & Frank, C. W. (2010). Hydrophobic nanoparticles improve permeability of cell-encapsulating poly(ethylene glycol) hydrogels while maintaining patternability. Proc Natl Acad Sci U S A, 107(48), 20709–20714. https://doi.org/10.1073/pnas.1005211107
Lee, Wonjae, Nam-Joon Cho, Anming Xiong, Jeffrey S. Glenn, and Curtis W. Frank. “Hydrophobic nanoparticles improve permeability of cell-encapsulating poly(ethylene glycol) hydrogels while maintaining patternability.Proc Natl Acad Sci U S A 107, no. 48 (November 30, 2010): 20709–14. https://doi.org/10.1073/pnas.1005211107.
Lee W, Cho N-J, Xiong A, Glenn JS, Frank CW. Hydrophobic nanoparticles improve permeability of cell-encapsulating poly(ethylene glycol) hydrogels while maintaining patternability. Proc Natl Acad Sci U S A. 2010 Nov 30;107(48):20709–14.
Lee, Wonjae, et al. “Hydrophobic nanoparticles improve permeability of cell-encapsulating poly(ethylene glycol) hydrogels while maintaining patternability.Proc Natl Acad Sci U S A, vol. 107, no. 48, Nov. 2010, pp. 20709–14. Pubmed, doi:10.1073/pnas.1005211107.
Lee W, Cho N-J, Xiong A, Glenn JS, Frank CW. Hydrophobic nanoparticles improve permeability of cell-encapsulating poly(ethylene glycol) hydrogels while maintaining patternability. Proc Natl Acad Sci U S A. 2010 Nov 30;107(48):20709–20714.
Journal cover image

Published In

Proc Natl Acad Sci U S A

DOI

EISSN

1091-6490

Publication Date

November 30, 2010

Volume

107

Issue

48

Start / End Page

20709 / 20714

Location

United States

Related Subject Headings

  • Viscosity
  • Reference Standards
  • Polylactic Acid-Polyglycolic Acid Copolymer
  • Polyglycolic Acid
  • Polyethylene Glycols
  • Phenotype
  • Nanoparticles
  • Molecular Weight
  • Materials Testing
  • Lactic Acid